Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study

Erdeljić, Viktorija and Francetić, Igor and Macolić Šarinić, Viola and Bilušić, Marinko and Makar-Aušperger, Ksenija and Huić, Mirjana and Merčep, Iveta (2006) Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study. Pharmacy World & Science, 28 (5). pp. 318-325. ISSN 0928-1231 (Print) 1573-739X (Electronic)

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    English abstract

    OBJECTIVE: In recent years, studies investigated to what extend recommendations for co-prescribing gastroprotective agents in prevention of NSAID-induced gastrointestinal complications are followed in clinical practice. However, only a few studies have also taken into consideration the recommended dose of gastroprotectives prescribed in NSAID-induced ulcer prophylaxis. The aim of our study was to evaluate the prevalence of concomitant use of gastroprotectives with NSAIDs in hospitalized patients, with emphasis on the recommended dose of gastroprotectives for ulcer prophylaxis. - - - - - METHOD: This observational, cross-sectional, drug utilization study included all adult patients receiving NSAIDs hospitalized in the Clinical Hospital Center Zagreb on the day of the study. Data on age, sex, comorbidities, indications for NSAID use, type/dose of NSAIDs and gastroprotectives, history of gastrointestinal events, active gastrointestinal symptoms and risk factors were evaluated. - - - - - MAIN OUTCOME MEASURE: Study outcomes were: (1) prevalence of prescription of gastroprotectives among NSAID-users at risk; (2) prevalence of prescription of gastroprotective in recommended dose; (3) association between risk factors and prescription of GPAs. - - - - - RESULTS: The rates of gastroprotectives prescription were significantly higher in NSAID-users with concomitant risk factors as compared to patients without risk factors [47/70 (67.1%) and 8/22 (36.4%), respectively; p = 0.01072]. However, gastroprotection in recommended ulcer-preventive dose was low in both groups [8/70 (11.4%) and 9/92 (9.8%), respectively]. The number of concomitant risk factors did not increase the odds of receiving anti-ulcer therapy (odds ratio 0.7279). Thirty-three percent of patients with concomitant risk factors were not prescribed gastroprotectives. Ibuprofen, NSAID with the lowest risk of inducing gastrointestinal complications, was prescribed in only two patients. - - - - - CONCLUSION: The results indicate high awareness among hospital physicians about possible NSAID-induced gastrointestinal complications, but insufficient knowledge about risk factors related to NSAID-induced gastrointestinal toxicity, recommended dose of gastroprotectives in NSAID-induced ulcer prophylaxis and gastrointestinal toxicity of different types of NSAIDs.

    Item Type: Article
    MeSH: Hospitalization ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage - adverse effects - therapeutic use ; Gastrointestinal Diseases - drug therapy ; Aged ; Drug Utilization - statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Risk Factors
    Divisions: Katedra za internu medicinu
    Depositing User: Lea Škorić
    Status: Published
    Creators:
    CreatorsEmail
    Erdeljić, Viktorija
    Francetić, Igor
    Macolić Šarinić, Viola
    Bilušić, Marinko
    Makar-Aušperger, Ksenija
    Huić, Mirjana
    Merčep, Iveta
    Date: October 2006
    Date Deposited: 06 Feb 2007
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/209

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