Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer.

Kovačević, Dujo and Sonicki, Zdenko and Kusić, Zvonko and Bolanča, Ante and Grubišić, Goran and Lukač, Maja and Lukač, Josip (2007) Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer. International Journal of Colorectal Disease, 22 (7). pp. 827-831. ISSN 0179-1958 (Print) 1432-1262 (Electronic)

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Abstract

BACKGROUND AND AIM: Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial. The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients. - - - - - MATERIALS AND METHODS: Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery. - - - - - RESULTS: Preoperative serum c-erbB-2 levels were significantly higher in stage IV patients than in healthy controls (P<0.001) and did not show correlation with preoperative CEA levels. Elevated preoperative serum c-erbB-2 levels showed relatively high specificity (88%) and low sensitivity (44%) in the diagnosis of rectal cancer. Elevated preoperative oncoprotein levels were predictive neither for overall survival nor for development of local recurrence/distant metastases. - - - - - CONCLUSION: Although preoperative serum c-erbB-2 levels were significantly higher in rectal cancer patients than in healthy controls, the soluble c-erbB-2 does not seem to be useful in the diagnosis of rectal cancer due to its low sensitivity. Preoperative serum levels of this oncoprotein were predictive neither for overall survival nor for local recurrence/distant metastases in rectal cancer patients.

Item Type: Article
MeSH: Colectomy ; Adenocarcinoma - blood - mortality - surgery ; Receptor, erbB-2 - blood ; Rectal Neoplasms - blood - surgery ; Tumor Markers, Biological - blood ; Adult ; Aged ; Carcinoembryonic Antigen - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Preoperative Care ; Prognosis ; Survival Rate ; Time Factors
Departments: Katedra za radiologiju i opću kliničku onkologiju
Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
Depositing User: Lea Škorić
Status: Published
Creators:
CreatorsEmail
Kovačević, DujoUNSPECIFIED
Sonicki, ZdenkoUNSPECIFIED
Kusić, ZvonkoUNSPECIFIED
Bolanča, AnteUNSPECIFIED
Grubišić, GoranUNSPECIFIED
Lukač, MajaUNSPECIFIED
Lukač, JosipUNSPECIFIED
Date: July 2007
Date Deposited: 05 Oct 2007
Last Modified: 23 Sep 2011 16:10
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/208

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