Prevalence of Coxiella burnetii antibodies among febrile patients in Croatia, 2008-2010

Vilibić-Čavlek, Tatjana and Kučinar, Jasmina and Ljubin-Sternak, Sunčanica and Kolarić, Branko and Kaić, Bernard and Lazarić-Stefanović, Lorena and Hunjak, Blaženka and Mlinarić-Galinović, Gordana (2012) Prevalence of Coxiella burnetii antibodies among febrile patients in Croatia, 2008-2010. Vector Borne and Zoonotic Diseases, 12 (4). pp. 293-296. ISSN 1530-3667

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Despite the widespread distribution of Q fever, the prevalence in humans is not accurately known, because many infected people seroconvert without symptoms or with a mild febrile disease. The aim of this study was to determine the seroprevalence of Q fever in different regions of Croatia. During a 2-year period (2008-2010), serum samples from 552 febrile patients with prolonged cough aged 1-88 were tested for the presence of Coxiella burnetii antibodies by using indirect immunofluorescent assay. Sera from 27.5% patients showed IgG antibodies. Serological evidence of C. burnetii infection was found in patients from all parts of Croatia. Seroprevalence rates significantly differed among regions from 21.5% to 41.2% (p=0.001). Men were more often seropositive (31.6%) than women (22.2%; p=0.016). According to age, a progressive increase in the IgG seropositivity rates was observed as ranging from 6.7% in children less than 10 years of age to 39.2% in patients aged 40-49 (p=0.001). Above the age of 50, the IgG seroprevalence remained stable. Patients from rural areas were more often seropositive than patients from urban areas (40.8% vs. 19%), p<0.001). Acute Q fever was confirmed in 5.8% of patients. Cases occurred throughout the year. A majority of cases were reported during summer months.

Item Type: Article
MeSH: Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antibodies, Bacterial/blood ; Child ; Child, Preschool ; Cough/epidemiology ; Cough/immunology ; Cough/microbiology ; Coxiella burnetii/immunology ; Coxiella burnetii/isolation & purification ; Coxiella burnetii/pathogenicity ; Croatia/epidemiology ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Male ; Middle Aged ; Q Fever/epidemiology ; Q Fever/immunology ; Q Fever/microbiology ; Rural Population ; Seasons ; Seroepidemiologic Studies ; Urban Population ; Young Adult
Departments: Katedra za bakteriologiju, virologiju i parasitologiju
Depositing User: Marijan Šember
Status: Published
Vilibić-Čavlek, TatjanaUNSPECIFIED
Kučinar, JasminaUNSPECIFIED
Ljubin-Sternak, SunčanicaUNSPECIFIED
Kolarić, BrankoUNSPECIFIED
Lazarić-Stefanović, LorenaUNSPECIFIED
Hunjak, BlaženkaUNSPECIFIED
Mlinarić-Galinović, GordanaUNSPECIFIED
Date: April 2012
Date Deposited: 26 Feb 2014 11:27
Last Modified: 10 Jul 2020 07:48
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