Topić, Iva and Ikić, Marina and Ivčević, Sanja and Kovačić, Nataša and Marušić, Ana and Kušec, Rajko and Grčević, Danka (2013) Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells. Leukemia Research, 37 (6). pp. 705-712. ISSN 0145-2126
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Abstract
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.
| Item Type: | Article | ||||||||||||||||
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| MeSH: | Bone Morphogenetic Protein 2/pharmacology ; Bone Morphogenetic Protein 2/physiology ; Bone Morphogenetic Protein 4/pharmacology ; Bone Morphogenetic Protein 4/physiology ; Bone Morphogenetic Protein 6/pharmacology ; Bone Morphogenetic Protein 6/physiology ; Bone Morphogenetic Proteins/metabolism ; Bone Morphogenetic Proteins/pharmacology ; Bone Morphogenetic Proteins/physiology ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Gene Expression Regulation, Leukemic/drug effects ; Gene Expression Regulation, Leukemic/genetics ; Granulocyte Precursor Cells/drug effects ; Granulocyte Precursor Cells/metabolism ; Granulocyte Precursor Cells/physiology ; HL-60 Cells ; Humans ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/pathology ; Leukemia, Promyelocytic, Acute/physiopathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/physiology ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Tretinoin/pharmacology ; Tumor Cells, Cultured | ||||||||||||||||
| Departments: | Katedra za anatomiju i kliničku anatomiju Katedra za fiziologiju i imunologiju Katedra za internu medicinu Katedra za otorinoloringologiju s audiologijom i fonijatrijom |
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| Depositing User: | Marijan Šember | ||||||||||||||||
| Status: | Published | ||||||||||||||||
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| Date: | June 2013 | ||||||||||||||||
| Date Deposited: | 26 Feb 2014 09:57 | ||||||||||||||||
| Last Modified: | 15 Jul 2020 10:17 | ||||||||||||||||
| Subjects: | / | ||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/2058 |
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