An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization.

Verbanac, Donatella and Jain, Subhash C. and Jain, Nidhi and Chand, Mahesh and Čipčić Paljetak, Hana and Matijašić, Mario and Perić, Mihaela and Stepanić, Višnja and Saso, Luciano (2012) An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. Bioorganic & Medicinal Chemistry, 20 (10). pp. 3180-5. ISSN 0968-0896

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Abstract

Xanthones and their thio-derivatives are a class of pleiotropic compounds with various reported pharmacological and biological activities. Although these activities are mainly determined in laboratory conditions, the class itself has a great potential to be utilized as promising chemical scaffold for the synthesis of new drug candidates. One of the main obstacles in utilization of these compounds was related to the difficulties in their chemical synthesis. Most of the known methods require two steps, and are limited to specific reagents not applicable to a large number of starting materials. In this paper a new and improved method for chemical synthesis of xanthones is presented. By applying a new procedure, we have successfully obtained these compounds with the desired regioselectivity in a shorter reaction time (50s) and with better yield (>80%). Finally, the preliminary in vitro screenings on different bacterial species and cytotoxicity assessment, as well as in silico activity evaluation were performed. The obtained results confirm potential pharmacological use of this class of molecules.

Item Type: Article
MeSH: Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Cell Line, Tumor ; Computer Simulation ; Humans ; Inhibitory Concentration 50 ; Microwaves ; Molecular Structure ; Structure-Activity Relationship ; Sulfhydryl Compounds/chemistry ; Xanthones/chemical synthesis ; Xanthones/chemistry ; Xanthones/pharmacology
Departments: Centar za translacijska i klinička istraživanja
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Verbanac, DonatellaUNSPECIFIED
Jain, Subhash C.UNSPECIFIED
Jain, NidhiUNSPECIFIED
Chand, MaheshUNSPECIFIED
Čipčić Paljetak, HanaUNSPECIFIED
Matijašić, MarioUNSPECIFIED
Perić, MihaelaUNSPECIFIED
Stepanić, VišnjaUNSPECIFIED
Saso, LucianoUNSPECIFIED
Date: 15 May 2012
Date Deposited: 24 Feb 2014 12:55
Last Modified: 24 Feb 2014 12:55
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2056

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