A pilot study of transrectal endoscopic ultrasound elastography in inflammatory bowel disease

Rustemović, Nadan and Čuković-Čavka, Silvija and Brinar, Marko and Radić, Davor and Opačić, Milorad and Ostojić, Rajko and Vucelić, Boris (2011) A pilot study of transrectal endoscopic ultrasound elastography in inflammatory bowel disease. BMC Gastroenterology, 11. p. 113. ISSN 1471-230X

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Abstract

BACKGROUND: Using standard diagnostic algorithms it is not always possible to establish the correct phenotype of inflammatory bowel disease which is essential for therapeutical decisions. Endoscopic ultrasound elastography is a new endoscopic procedure which can differentiate the stiffness of normal and pathological tissue by ultrasound. Therefore, we aimed to investigate the role of transrectal ultrasound elastography in distiction between Crohn's disease and ulcerative colitis. ----- METHODS: A total 30 Crohn's disease, 25 ulcerative colitis, and 28 non-inflammatory bowel disease controls were included. Transrectal ultrasound elastography was performed in all patients and controls. In all ulcerative coltis patients and 80% of Crohn's disease patients endoscopy was performed to assess disease activity in the rectum. ----- RESULTS: Significant difference in rectal wall thickness and strain ratio was detected between patients with Crohn's disease and controls (p = 0.0001). CD patients with active disease had higher strain ratio than patients in remission (p = 0.02). In ulcerative colitis group a significant difference in rectal wall thickness was found between controls and patients with active disease (p = 0.03). A significant difference in rectal wall thickness (p = 0.02) and strain ratio (p = 0.0001) was detected between Crohn's disease and ulcerative colitis patient group. Crohn's disease patients with active disease had a significantly higher strain ratio compared to ulcerative colitis patients with active disease (p = 0.0001). ----- CONCLUSION: Transrectal ultrasound elastography seems to be a promising new diagnostic tool in the field of inflammatory bowel disease. Further study on a larger cohort of patients is needed to definitely assess the role of transrectal ultrasound elastography in inflammatory bowel disease.

Item Type: Article
Additional Information: THE WORK IS PROVIDED UNDER THE TERMS OF THIS BIOMED CENTRAL OPEN ACCESS LICENSE. THE WORK IS PROTECTED BY COPYRIGHT AND/OR OTHER APPLICABLE LAW. ANY USE OF THE WORK OTHER THAN AS AUTHORIZED UNDER THIS LICENSE IS PROHIBITED (http://www.biomedcentral.com/about/license).
MeSH: Adolescent ; Adult ; Case-Control Studies ; Colitis, Ulcerative/ultrasonography ; Crohn Disease/ultrasonography ; Elasticity Imaging Techniques ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Rectum/ultrasonography ; Young Adult
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Rustemović, NadanUNSPECIFIED
Čuković-Čavka, SilvijaUNSPECIFIED
Brinar, MarkoUNSPECIFIED
Radić, DavorUNSPECIFIED
Opačić, MiloradUNSPECIFIED
Ostojić, RajkoUNSPECIFIED
Vucelić, BorisUNSPECIFIED
Date: 20 October 2011
Date Deposited: 20 Feb 2014 12:38
Last Modified: 07 Jul 2020 08:42
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2054

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