Leptomeningeal and intramedullary metastases of glioblastoma multiforme in a patient reoperated during adjuvant radiochemotherapy

Grah, Josip Joachim and Katalinić, Darko and Štern-Padovan, Ranka and Paladino, Josip and Šantek, Fedor and Juretić, Antonio and Žarković, Kamelija and Pleština, Stjepko and Šupe, Marijana (2013) Leptomeningeal and intramedullary metastases of glioblastoma multiforme in a patient reoperated during adjuvant radiochemotherapy. World Journal of Surgical Oncology, 11 (1). p. 55. ISSN 1477-7819

[img]
Preview
PDF - Published Version
Download (1MB) | Preview

Abstract

Despite huge advances in medicine, glioblastoma multiforme (GBM) remains a highly lethal, fast-growing tumour that cannot be cured by currently available therapies. However, extracranial and extraneural dissemination of GBM is extremely rare, but is being recognised in different imaging studies. To date, the cause of the GBM metastatic spread still remains under discussion. It probably develops at the time of intracranial progression following a surgical procedure. According to other hypothesis, the metastases are a consequence of spontaneous tumour transdural extension or haematogenous dissemination. We present a case of a 59-year-old woman with symptomatic leptomeningeal and intramedullary metastases of GBM who has been previously surgically treated with primary subtotal resection and underwent a repeated surgery during adjuvant radiotherapy and chemotherapy with temozolomide. Today, the main goal of surgery and chemoradiotherapy is to prevent neurologic deterioration and improve health-related quality of life. With this paper, we want to present this rare entity and emphasise the importance of a multidisciplinary approach, a key function in the management of brain tumour patients. The prognosis is still very poor although prolongation of survival can be obtained. Finally, although rare, our case strongly suggests that clinicians should be familiar with the possibility of the extracranial spread of GBM because as treatment improvements provide better control of the primary tumour and improving survival, metastatic disease will be increasingly encountered.

Item Type: Article
Additional Information: THE WORK IS PROVIDED UNDER THE TERMS OF THIS BIOMED CENTRAL OPEN ACCESS LICENSE. THE WORK IS PROTECTED BY COPYRIGHT AND/OR OTHER APPLICABLE LAW. ANY USE OF THE WORK OTHER THAN AS AUTHORIZED UNDER THIS LICENSE IS PROHIBITED (http://www.biomedcentral.com/about/license).
MeSH: Antineoplastic Agents, Alkylating/therapeutic use ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Chemoradiotherapy, Adjuvant ; Combined Modality Therapy ; Dacarbazine/analogs & derivatives ; Dacarbazine/therapeutic use ; Female ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Meningeal Neoplasms/secondary ; Meningeal Neoplasms/therapy ; Middle Aged ; Muscle Weakness ; Prognosis ; Reoperation ; Spinal Cord Neoplasms/secondary ; Spinal Cord Neoplasms/therapy
Departments: Katedra za neurologiju
Katedra za patologiju
Katedra za radiologiju i opću kliničku onkologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Grah, Josip JoachimUNSPECIFIED
Katalinić, DarkoUNSPECIFIED
Štern-Padovan, RankaUNSPECIFIED
Paladino, JosipUNSPECIFIED
Šantek, FedorUNSPECIFIED
Juretić, AntonioUNSPECIFIED
Žarković, KamelijaUNSPECIFIED
Pleština, StjepkoUNSPECIFIED
Šupe, MarijanaUNSPECIFIED
Date: March 2013
Date Deposited: 05 Feb 2014 13:00
Last Modified: 13 Jul 2020 08:19
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2037

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year