The role of optical coherence tomography (OCT) in optic neuritis (ON) [Važnost optičke koherentne tomografije (OCT) kod optičkog neuritisa (ON)]

Cerovski, Branimir and Barišić Kutija, Marija and Vidović, Tomislav and Popović-Suić, Smiljka and Jandroković, Sonja and Kordić, Rajko and Vidas, Sania (2013) The role of optical coherence tomography (OCT) in optic neuritis (ON) [Važnost optičke koherentne tomografije (OCT) kod optičkog neuritisa (ON)]. Collegium Antropologicum, 37 (S. 1). pp. 121-125. ISSN 0350-6134

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Abstract

Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal layers. Our aim was to examine retinal nerve fiber layer (RNFL) thickness and macular volume (MV), measred by OCT in patients with history of optic neuritis (ON). Patients with chronic ON had significantly decreased mean RNFL thickness and total MV when compared to acute ON eyes, controls and unaffected fellow eyes. There was also statistically significant difference between two chronic groups, with lower values in group with history of acute ON. OCT provides us unique insight in structural changes in the anterior visual pathway, therefore it may complement our existing diagnostic tests and, as a potential outcome measure, help develop more effective therapeutic strategies for ON and MS patients.

Abstract in Croatian

Degeneracija aksona i neurona je važna u patogenezi multiple skleroze (MS) i kod drugih neuroloških bolesti koje zahvaćaju prednji dio vidnog puta. Optička koherentna tomografija (OCT) je neinvazivna tehnika koja omogućava snimanje sloja retinalnih živčanih vlakana (RNFL). Cilj našeg ispitivanja bio je ispitati debljinu RNFL i volumen makule (VM) kod pacijenata s optičkim neuritisom (ON), mjerene OCT-om. Kada smo ih usporedili s očima s akutnim ON, sa nezahvaćenim drugim okom i kontrolnom skupinom, oči pacijenata s kroničnim ON su imale značajno snižene srednje vrijednosti debljine RNFL-a (mRNFL) i ukupnog VM. Također smo dobili statistički značajnu razliku između dvije kronične grupe, s nižim vrijednostima u grupi s prethodnim akutnim ON. OCT omogućuje jedinstven uvid u strukturalne promjene prednjeg dijala vidnog puta, te može dopuniti uobičajeni spektar pretraga i pomoći u razvijanju efikasnijih strategija liječenja pacijenata s ON i MS.

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