Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)

Sartelli, Massimo and Catena, Fausto and Ansaloni, Luca and Moore, Ernest and Malangoni, Mark and Velmahos, George and Coimbra, Raul and Koike, Kaoru and Leppaniemi, Ari and Biffl, Walter and Balogh, Zsolt and Bendinelli, Cino and Gupta, Sanjay and Kluger, Yoram and Agresta, Ferdinando and di Saverio, Salomone and Tugnoli, Gregorio and Jovine, Elio and Ordonez, Carlos and Gomes, Carlos Augusto and Junior, Gerson Alves Pereira and Yuan, Kuo-Ching and Bala, Miklosh and Peev, Miroslav P and Cui, Yunfeng and Marwah, Sanjay and Zachariah, Sanoop and Sakakushev, Boris and Kong, Victor and Ahmed, Adamu and Abbas, Ashraf and Gonsaga, Ricardo Alessandro Teixeira and Guercioni, Gianluca and Vettoretto, Nereo and Poiasina, Elia and Ben-Ishay, Offir and Díaz-Nieto, Rafael and Massalou, Damien and Skrovina, Matej and Gerych, Ihor and Augustin, Goran and Kenig, Jakub and Khokha, Vladimir and Tranà, Cristian and Kok, Kenneth Yuh Yen and Mefire, Alain Chichom and Lee, Jae Gil and Hong, Suk-Kyung and Lohse, Helmut Alfredo Segovia and Ghnnam, Wagih and Verni, Alfredo and Lohsiriwat, Varut and Siribumrungwong, Boonying and Tavares, Alberto and Baiocchi, Gianluca and Das, Koray and Jarry, Julien and Zida, Maurice and Sato, Norio and Murata, Kiyoshi and Shoko, Tomohisa and Irahara, Takayuki and Hamedelneel, Ahmed O and Naidoo, Noel and Adesunkanmi, Abdul Rashid Kayode and Kobe, Yoshiro and Attri, AK and Sharma, Rajeev and Coccolini, Federico and El Zalabany, Tamer and Khalifa, Khalid Al and Sanjuan, Juan and Barnabé, Rita and Ishii, Wataru (2013) Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study). World Journal of Emergency Surgery, 8 (1). p. 1. ISSN 1749-7922

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Abstract

Despite advances in diagnosis, surgery, and antimicrobial therapy, mortality rates associated with complicated intra-abdominal infections remain exceedingly high. The World Society of Emergency Surgery (WSES) has designed the CIAOW study in order to describe the clinical, microbiological, and management-related profiles of both community- and healthcare-acquired complicated intra-abdominal infections in a worldwide context. The CIAOW study (Complicated Intra-Abdominal infection Observational Worldwide Study) is a multicenter observational study currently underway in 57 medical institutions worldwide. The study includes patients undergoing surgery or interventional drainage to address complicated intra-abdominal infections. This preliminary report includes all data from almost the first two months of the six-month study period. Patients who met inclusion criteria with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 702 patients with a mean age of 49.2 years (range 18-98) were enrolled in the study. 272 patients (38.7%) were women and 430 (62.3%) were men. Among these patients, 615 (87.6%) were affected by community-acquired IAIs while the remaining 87 (12.4%) suffered from healthcare-associated infections. Generalized peritonitis was observed in 304 patients (43.3%), whereas localized peritonitis or abscesses was registered in 398 (57.7%) patients.The overall mortality rate was 10.1% (71/702). The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013.

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