Therapeutic hypothermia for severe adult Herpes simplex virus encephalitis.

Kutleša, Marko and Baršić, Bruno (2012) Therapeutic hypothermia for severe adult Herpes simplex virus encephalitis. Wiener Klinische Wochenschrift, 124 (23-24). pp. 855-8. ISSN 0043-5325

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Despite antiviral treatment and advances in critical care, the Herpes simplex encephalitis (HSE) still has a poor outcome in a significant portion of patients. In severe cases of HSE, reduced carbon dioxide reactivity is usually present and these patients don't respond to the usual treatment of brain edema and intracranial hypertension. We present case series of patients with severe form of HSE treated with therapeutic hypothermia (TH) and describe in detail the indications, methods, and the rationale for its use. In this case series, patients presented with severely impaired consciousness and very high predicted death rate as measured by Glasgow coma scale and Acute Physiology and Chronic Health Evaluation (APACHE II) score respectively. According to our findings, TH in carefully selected patients with HSE holds promise as an adjunctive to the antiviral treatment.

Item Type: Article
MeSH: Acyclovir/administration & dosage ; Aged ; Antiviral Agents/administration & dosage ; Brain Edema/diagnosis ; Brain Edema/therapy ; Carbon Dioxide/blood ; Disease Progression ; Encephalitis, Herpes Simplex/diagnosis ; Encephalitis, Herpes Simplex/therapy ; Encephalocele/diagnosis ; Encephalocele/therapy ; Glasgow Coma Scale ; Humans ; Hypothermia, Induced/methods ; Infusions, Intravenous ; Male ; Middle Aged ; Optic Nerve/pathology ; Oximetry ; Prognosis ; Tomography, X-Ray Computed ; Ultrasonography, Doppler, Transcranial
Departments: Katedra za infektologiju
Depositing User: Marijan Šember
Status: Published
Date: December 2012
Date Deposited: 24 Oct 2013 11:44
Last Modified: 24 Oct 2013 11:44
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