Fever of unknown origin: large vessel vasculitis diagnosed by PET/CT

Bosnić, Dubravka and Barešić, Marko and Padjen, Ivan and Balenović, Antonija and Žarković, Kamelija and Anić, Branimir (2013) Fever of unknown origin: large vessel vasculitis diagnosed by PET/CT. Rheumatology International, 33 (9). pp. 2417-2421. ISSN 0172-8172

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PET/CT is starting to play an important role in evaluating fever of unknown origin (FUO), due to its ability to localize and delineate areas of high metabolic activity, such as neoplastic proliferation and inflammation, including vasculitis. We present a case of giant cell arteritis (GCA) in a 72-year-old female patient admitted to our department with a 4-month history of FUO, weight loss and fatigue, without specific symptoms or signs. Laboratory investigations suggested acute phase response, with a pronounced erythrocyte sedimentation rate, high CRP level and microcytic anemia. A thorough diagnostic evaluation was performed to exclude an unknown primary tumor, which was initially suspected due to a positive family history of cancer. Surprisingly, PET/CT revealed large vessel vasculitis affecting the ascending, descending and abdominal aorta, as well as subclavian, proximal brachial and carotid arteries bilaterally. Biopsy of the superficial temporal artery confirmed the diagnosis of GCA. Treatment with methylprednisolone and azathioprine led to resolution of clinical symptoms and normalization of laboratory parameters. In addition to the use of PET/CT in the evaluation of FUO, its value as a method complementary to temporal artery biopsy is also discussed.

Item Type: Article
MeSH: Aged ; Female ; Fever of Unknown Origin / diagnosis ; Giant Cell Arteritis / diagnosis ; Humans ; Positron-Emission Tomography / methods ; Tomography, X-Ray Computed / methods
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Bosnić, DubravkaUNSPECIFIED
Balenović, AntonijaUNSPECIFIED
Žarković, KamelijaUNSPECIFIED
Date: September 2013
Date Deposited: 27 Sep 2013 10:09
Last Modified: 10 Jul 2020 10:28
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1937

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