"Compensated hyperosmolarity" of cerebrospinal fluid and the development of hydrocephalus

Klarica, Marijan and Miše, Branko and Vladić, Anton and Radoš, Milan and Orešković, Darko (2013) "Compensated hyperosmolarity" of cerebrospinal fluid and the development of hydrocephalus. Neuroscience, 248. pp. 278-289. ISSN 0306-4522

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Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of 3H2O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly faster, hence causing a significant increase in intracranial pressure. The noted phenomenon in which intracranial pressure still significantly increases, but in which the hyperosmolarity of the cerebrospinal fluid is no longer present, was named "compensated hyperosmolarity". In the case of the sub-chronic application of hyperosmolar solutions into cat ventricles, we observed an increase in cerebrospinal fluid volume and a more pronounced development of hydrocephalus in the area of application, but without significant increase in intracranial pressure and without blockage of cerebrospinal fluid pathways. These results support the newly proposed hypothesis of cerebrospinal fluid hydrodynamics and the ability to develop new strategies for the treatment of cerebrospinal fluid-related diseases. ----- KEYWORDS: CM, CP, CSF, HRP, ICP, ISF, LLV, RLV, SAS, SD, cerebrospinal fluid, cerebrospinal fluid hydrodynamics, cerebrospinal fluid hyperosmolarity, choroid plexus, cisterna magna, horseradish peroxidase, hydrocephalus, interstitial fluid, intracranial pressure, left lateral ventricle, right lateral ventricle, standard deviation, subarachnoid space

Item Type: Article
Additional Information: Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
MeSH: Animals ; Cats ; Cerebral Ventricles / physiopathology ; Cerebrospinal Fluid / metabolism ; Dogs ; Hydrocephalus / metabolism ; Hydrocephalus / physiopathology ; Hydrodynamics ; Intracranial Pressure ; Lateral Ventricles / physiopathology ; Osmotic Pressure
Departments: Hrvatski institut za istraživanje mozga
Katedra za farmakologiju
Depositing User: Marijan Šember
Status: Published
Klarica, MarijanUNSPECIFIED
Orešković, DarkoUNSPECIFIED
Date: 24 June 2013
Date Deposited: 26 Sep 2013 12:25
Last Modified: 13 Jul 2020 10:21
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1936

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