Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma [Klinički i patohistološki čimbenici koji utječu na petogodišnju stopu preživljavanja u populaciji žena s invazivnim duktalnim karcinomom dojke u Hrvatskoj]

Milanović, Rudolf and Roje, Željka and Korušić, Anđelko and Tudorić Đeno, Ivana and Barić, Ada and Stanec, Zdenko (2013) Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma [Klinički i patohistološki čimbenici koji utječu na petogodišnju stopu preživljavanja u populaciji žena s invazivnim duktalnim karcinomom dojke u Hrvatskoj]. Collegium Antropologicum, 37 (2). pp. 459-464. ISSN 0350-6134

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Abstract

Breast carcinoma falls into a heterogeneous group of diseases which can be determined by various prognostic factors. The identification of clinical and histopathologic factors is of great value in predicting the progression of tumor growth and survival outcome. Due to a high degree of cell proliferation in breast tumors and high genetic instability of these tumors, as a consequence of defective DNA repair mechanisms, chemotherapy as a treatment option often renders very successful results. During our scientific study of the expression of genes responsible for mismatch repair of DNA in cells of invasive ductal carcinoma we also compared the patient survival rate with the major prognostic factors. This study included 108 patients who were surgically treated for invasive breast cancer at the Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital "Dubrava". The overall survival rate was compared to factors such as initial tumor stage, regional lymph node involvement and distant metastasis. The overall five year survival rate of our patients was 78.7%. Patients without the presence of distant metastasis, a lower rate of local lymph node involvement and a lower. tumor stage statistically had a longer overall survival period. It is important that physicians recognize the various clinico-pathohistological factors in patients with breast carcinoma. This study confirms that this prognostic factors determine the type of treatment required and most important, the patient overall survival period.

Abstract in Croatian

Karcinom dojke spada u heterogenu grupu bolesti na koju utječu mnogi prognostički čimbenici. Identifikacija kliničkih i patohistoloških čimbenika je od velike važnosti u predviđanju progresije tumorskog rasta i stope preživljena pacijentica. Zbog visokog stupnja proliferacije stanica tumora dojke i genetske nestabilnosti tih tumora, kao posljedice nepravilnog mehanizma za popravak oštećenja DNA, kemoterapija kao terapijska opcija daje vrlo dobre rezultate. U sklopu istraživanja ekspresije gena odgovornih za popravak krivo sparenih baza u molekuli DNA u stanicama invazivnog duktalni karcinoma, provedena je i usporedba stope preživljenja i glavnih prognostičkih čimbenika. U ovo istraživanje uključeno je 108 pacijentica koje su kirurški liječene zbog invazivnog karcinoma dojke na Klinici za plastičnu, rekonstruktivnu i estetsku kirurgiju, KB »Dubrava«. Ukupna stopa preživljenja promatrana je u odnosu na početni stadij tumora, prisutnost regionalnih metastaza u limfnim čvorovima i udaljenih metastaza. Ukupna petogodišnja stopa preživljenja naših pacijenata bila je 78,7%. Pacijentice bez prisutnosti udaljenih metastaza, manjim stupnjem zahvaćenosti limfnih čvorova i nižim stadijem tumora statistički su imale bolju stopu preživljenja. Ova studija potvrđuje da navedeni prognostički čimbenici određuju način liječenja i najvažnije, utječu na preživljenje pacijentica.

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