Neuroendocrine tumors of larynx - two case reports and literature review [Neuroendokrini tumori larinksa - prikaz slučaja i pregled literature]

Carić, Tomislav and Bilić, Mario and Kovač Bilić, Lana and Prgomet, Drago and Kovačić, Jelena and Topić Grahovac, Iva and Hutinec, Zdenka (2012) Neuroendocrine tumors of larynx - two case reports and literature review [Neuroendokrini tumori larinksa - prikaz slučaja i pregled literature]. Collegium Antropologicum, 36 (S. 2). pp. 173-178. ISSN 0350-6134

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Abstract

Neuroendocrine tumors (NET) of the larynx are rare and heterogenous group, with much confusion about nature and classification of these neoplasms in the past. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy. A classification in 4 different types; paraganglioma, typical carcinoid, atypical carcinoid and small cell neuroendocrine carcinoma (SCNC) is a current consensus. Thorough diagnostic and a proper classification of neuroendocrine neoplasms are of paramount importance--prognosis and treatment differ significantly. We present two cases: 63-year old patient with SCNC of the larynx and a 53-year old patient with atypical carcinoid of the larynx. OctreoScan is useful tools for diagnostics and follow up of the patients and it is predictive for effectiveness of octreotide therapy.

Abstract in Croatian

Neuroendokrini tumori larinksa rijetka su i heterogena grupa neoplazmi o čijoj prirodi i podjeli je u prošlosti bilo dosta proturječja. Dijagnoza bolesti postavlja se primarno svjetlosnom mikroskopijom, a potvrđuje imunohistokemijom i elektronskom mikroskopijom. Suvremeni konsenzus je podjela neuroendokrinih tumora na 4 tipa: paragangliom, tipični karcinoid, atipični karcinoid i karcinom malih stanica. Precizna dijagnostika i klasifikacija neuroendokrinih tumora od najveće je važnosti – prognoza i način liječenja uvelike se razlikuju. Predstavljamo dva slučaja: 63-godišnjeg bolesnika sa karcinomom malih stanica i 53-godišnjeg bolesnika sa atipičnim karcinoidom larinksa. Oktreosken je važan za dijagnostiku i praćenje bolesnika te prediktivan za efikasnost terapije oktreotidom.

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