Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy

Horvatić, Ivica and Galešić Ljubanović, Danica and Bulimbašić, Stela and Knotek, Mladen and Prkačin, Ingrid and Tišljar, Miroslav and Galešić, Krešimir (2012) Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy. Pathology, Research and Practice, 208 (11). pp. 662-7. ISSN 0344-0338

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Abstract

The purpose of our study was to investigate the prognostic value of clinical and pathological, in particular glomerular and tubulointerstitial morphometric variables in idiopathic membranous nephropathy (IMN). We prospectively followed 60 Caucasian patients diagnosed with idiopathic membranous nephropathy for at least 2 years or until primary outcome (≥50% permanent decrease in estimated glomerular filtration rate or death). Glomerular and tubulointerstitial morphometric variables at the time of renal biopsy were analyzed with respect to this outcome. Univariate analysis revealed that significant negative prognostic factors for this outcome were higher cholesterol and smaller albumin concentrations, higher creatinine and maximal 24-h proteinuria, higher grade of nephroangiosclerosis, higher glomerular basement membrane thickness and glomerulopathy index, higher interstitial fibrosis and tubular atrophy percentage and higher injury score. In multivariate analysis, only the maximal 24-h proteinuria and interstitial fibrosis and tubular atrophy percentage were independent predictors of this outcome. The results suggest that morphometric analysis, mainly quantitative measurement of interstitial fibrosis and tubular atrophy percentage, injury score, glomerular basement membrane thickness and glomerulopathy index could be used as an additional method for risk stratification of patients with idiopathic membranous nephropathy.

Item Type: Article
Departments: Katedra za internu medicinu
Katedra za patologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Horvatić, IvicaUNSPECIFIED
Galešić Ljubanović, DanicaUNSPECIFIED
Bulimbašić, StelaUNSPECIFIED
Knotek, MladenUNSPECIFIED
Prkačin, IngridUNSPECIFIED
Tišljar, MiroslavUNSPECIFIED
Galešić, KrešimirUNSPECIFIED
Date: 15 November 2012
Date Deposited: 04 Feb 2013 11:17
Last Modified: 04 Feb 2013 11:17
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1810

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