Clear cell variant of urothelial carcinoma in urinary bladder; a clinicopathological and immunohistochemical study--a case report.

Peršec, Zoran and Buković, Damir and Peršec, Jasminka and Rako, Duje and Ljubanović, Danica and Starčević, Vito and Župić, Tomislav and Pavić, Mato (2012) Clear cell variant of urothelial carcinoma in urinary bladder; a clinicopathological and immunohistochemical study--a case report. Collegium Antropologicum, 36 (3). pp. 1045-7. ISSN 0350-6134

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Abstract

The clear cell variant urothelial carcinoma of urinary bladder is very rare and unusual neoplasm defined histologically by clear cell pattern and glycogen-rich cytoplasm. Our case of clear cell carcinoma was diagnosed with immunohistochemistry stain. A 72-year-old man, presented with painless macroscopic hematuria in November 2007. Evaluation revealed papillary tumor in urinary bladder. A transurethral resection of the bladder tumor (TUR-Bt) was performed. Histopatologic evaluation showed superficial transitional cell carcinoma and carcinoma in situ. On three month follow-up, a solitary pedunculated tumor was detected again in the left wall of the urinary bladder. A repeated transurethral resection of the bladder tumor (reTUR-Bt) was performed in February 2008. The pathological diagnosis was difficult due to diffuse clear cell appearance. Immunohistochemistry stain showed urothelial carcinoma and finally it was diagnosed as clear cell variant. Urothelial carcinoma has many variants that show a variety of appearances and characteristics. These should be well known for evaluation and optimal treatment.

Abstract in Croatian

UROTELNI KARCINOM SVJETLIH STANICA MOKRAĆNOG MJEHURA; KLINIČKO-PATOLOŠKA I IMUNOHISTOKEMIJSKA ANALIZA – PRIKAZ SLUČAJA ----- Oblik urotelnog karcinoma mokraćnog mjehura svijetlih stanica vrlo je rijetka i neobična neoplazma definirana histološki svijetlim stanicama s citoplazmom bogatom glikogenom. Naš slučaj karcinoma svijetlih stanica dijagnosticiran je imunohistokemijski. Muškarac, u dobi od 72 godine, klinički prezentiran s bezbolnom makroskopskom hematurijom u studenom 2007. godine. Evaluacijom mokraćnog mjehura nađena je papilarna tvorba. Učinjena je transuretralna resekcija tumora mokraćnog mjehura (TUR). Histopatološka evaluacija pokazala je da se radi površnom karcinomu prijelaznog epitela i karcinomu in situ. Nakon 3 mjeseca praćenja, ponovno je otkriven solitarni pedunkularni tumor s lijeve lateralne strane mokraćnog mjehura. Ponovna transuretralna resekcija tumora mokraćnog mjehura (reTUR) učinjena je u veljači 2008. godine. Patološka dijagnoza je bila otežana zbog difuznog prisustva svijetlih stanica. Imunohistokemijska analiza je dokazala urotelni karcinom, te je postavljena konačna dijagnoza kao oblik urotelnog karcinoma svijetlih stanica. Urotelni karcinom ima mnogo varijanti koje pokazuju različite oblike i karakteristike. To bi trebalo uzeti u obzir kod evaluacije i izbora optimalnog liječenja.

Item Type: Article
MeSH: Aged ; Carcinoma, Renal Cell/classification ; Carcinoma, Renal Cell/pathology ; Humans ; Immunohistochemistry ; Male ; Urinary Bladder Neoplasms/classification ; Urinary Bladder Neoplasms/pathology ; Urothelium/pathology
Departments: Katedra za ginekologiju i opstetriciju
Katedra za patologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Peršec, ZoranUNSPECIFIED
Buković, DamirUNSPECIFIED
Peršec, JasminkaUNSPECIFIED
Rako, DujeUNSPECIFIED
Ljubanović, DanicaUNSPECIFIED
Starčević, VitoUNSPECIFIED
Župić, TomislavUNSPECIFIED
Pavić, MatoUNSPECIFIED
Date: September 2012
Date Deposited: 17 Jan 2013 09:24
Last Modified: 17 Jan 2013 09:24
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1765

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