Trends in prostate cancer incidence and mortality in Croatia, 1988-2008

Kuliš, Tomislav and Krhen, Ivan and Kaštelan, Željko and Znaor, Ariana (2012) Trends in prostate cancer incidence and mortality in Croatia, 1988-2008. Croatian Medical Journal, 53 (2). pp. 109-14. ISSN 0353-9504

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Abstract

AIM: To describe and interpret prostate cancer incidence and mortality trends in Croatia between 1988 and 2008. ----- METHODS: Incidence data for the period 1988-2008 were obtained from the Croatian National Cancer Registry. The number of prostate cancer deaths was obtained from the World Health Organization mortality database. We also used population estimates for Croatia from the Population Division of the Department of Economic and Social Affairs of the United Nations. Age standardized incidence and mortality rates were calculated by the direct standardization method. To describe time trends of incidence and mortality, joinpoint regression analysis was used. ----- RESULTS: Average age-standardized incidence rate between the first and last five-year period doubled, from 19.0/100,000 in 1988-1992 to 39.1 per 100,000 in 2004-2008. Age-standardized mortality rate increased by 6.9%, from 14.5 to 15.5 per 100,000. Joinpoint analysis of incidence identified two joinpoints. The increasing incidence trend started from 1997, with the estimated annual percent of change (EAPC) of 12.9% from 1997-2002 and of 4.1% from 2002-2008. Joinpoint analyses of mortality identified one joinpoint. Mortality trend first decreased, with EAPC of -3.0% from 1988-1995 to increase later with EAPC of 2.0% from 1995-2008. ----- CONCLUSION: The incidence of prostate cancer in Croatia has been on the increase since 1997. Trend in mortality is increasing, contrary to the trends in some higher-income countries. An improvement in the availability of different treatment modalities as well as establishing prostate cancer units could have a positive impact on prostate cancer mortality in Croatia.

Abstract in Croatian

Trendovi incidencije i mortaliteta od raka prostate u Hrvatskoj, 1988. do 2008. ----- Cilj Opisati i interpretirati trendove incidencije i mortaliteta od raka prostate u Hrvatskoj, 1988. do 2008. ----- Postupci Podaci o incidenciji prikupljeni su iz Hrvatskog registra za rak, dok su podaci o mortalitetu prikupljeni iz baze podataka o mortalitetu Svjetske zdravstvene organizacije. Korištene su populacijske procjene za Hrvatsku Populacijskog odsjeka Odjela za ekonomska i socijalna pitanja Ujedinjenih naroda. Stope incidencije i mortaliteta standardizirane po dobi izračunate su metodom izravne standardizacije. Kako bismo opisali trendove mortaliteta i incidencije, koristili smo regresijsku analizu uz pomoć točaka spajanja (engl, joinpoint regression analysis). ----- Rezultati Prosječna stopa incidencije standardizirana po dobi dvostruko je porasla između prvog i drugog analiziranog petogodišnjeg razdoblja, sa 19,0 po 100,000 od 1988.-1992. na 39,1 po 100,000 od 2004.-2008. Stopa mortaliteta standardizirana po dobi porasla je za 6,9%, sa 14,5 na 15,5 po 100,000. Analiza incidencije uz pomoć točaka spajanja identificirala je 2 točke spajanja. Trend incidencije počeo je rasti 1997., s procijenjenim godišnjim postotkom promjene (engl, EAPC) od 12,9% u razdoblju 1997.-2002. i od 4,1% u razdoblju 2002.-2008. Analiza mortaliteta identificirala je jednu točku spajanja. Trend mortaliteta najprije se smanjio, s EAPC-om od -3,0% u razdoblju 1988.-1995 pa porastao, s EAPC-om od 2.0%, u razdoblju 1995.-2008. ----- Zaključak Incidencija raka prostate u Hrvatskoj je u porastu od 1997. Trend mortaliteta također raste, suprotno trendovima u nekim razvijenijim zemljama. Porast dostupnosti različitih načina liječenja kao i osnivanje jedinica za liječenje raka prostate moglo bi imati pozitivan učinak na mortalitet od raka prostate u Hrvatskoj.

Item Type: Article
MeSH: Adult ; Croatia/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Prostatic Neoplasms/epidemiology ; Retrospective Studies ; Survival Rate/trends
Departments: Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
Katedra za urologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Kuliš, TomislavUNSPECIFIED
Krhen, IvanUNSPECIFIED
Kaštelan, ŽeljkoUNSPECIFIED
Znaor, ArianaUNSPECIFIED
Date: April 2012
Date Deposited: 28 Dec 2012 11:39
Last Modified: 28 Dec 2012 11:39
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1722

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