Incidence and mortality trends of gastric and colorectal cancers in Croatia, 1988-2008

Kirac, Iva and Šekerija, Mario and Šimunović, Iva and Zgaga, Lina and Vrdoljak, Danko Velimir and Kovačević, Dujo and Kuliš, Tomislav and Znaor, Ariana (2012) Incidence and mortality trends of gastric and colorectal cancers in Croatia, 1988-2008. Croatian Medical Journal, 53 (2). pp. 124-134. ISSN 0353-9504

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Abstract

AIM: To estimate the incidence and mortality trends of gastric and colorectal cancers in Croatia between 1988 and 2008. ----- METHODS: Incidence data for the period 1988-2008 were obtained from the Croatian National Cancer Registry. The number of deaths from gastric and colorectal cancers were obtained from the World Health Organization mortality database. Joinpoint regression analysis was used to describe changes in trends by sex. ----- RESULTS: Gastric cancer incidence rates declined steadily during the study period, with estimated annual percent change (EAPC) of -3.2% for men and -2.8% for women. Mortality rates in men decreased, with EAPC of -5.0% from 1988-1995 and -2.5% from 1995-2008. Mortality rates in women decreased, with EAPC of -3.2% throughout the study period. For colorectal cancer in men, joinpoint analysis revealed increasing trends of both incidence (EAPC 2.9%) and mortality (EAPC 2.1%). In women, the increase in incidence was not significant, but mortality rates in the last 15 years showed a significant increase (EAPC 1.1%). ----- CONCLUSION: The incidence and mortality trends of gastric cancer in Croatia are similar to other European countries, while the still increasing colorectal cancer mortality calls for more efficient prevention and treatment.

Abstract in Croatian

Trendovi incidencije i mortaliteta od karcinoma želuca i kolorektalnog karcinoma u Hrvatskoj, 1988.-2008. ----- Cilj Odrediti trendove incidencije i mortaliteta od karcinoma želuca i kolorektalnog karcinoma u Hrvatskoj između 1988. i 2008. ----- Postupci Podaci o incidenciji prikupljeni su iz Hrvatskog registra za rak, dok su podaci o mortalitetu prikupljeni iz baze podataka o mortalitetu Svjetske zdravstvene organizacije. Kako bismo opisali promjene u trendovima ovisno o spolu proveli smo regresijsku analizu uz pomoć točaka spajanja (engl, joinpoint regression analysis). ----- Rezultati Stope incidencije karcinoma želuca konstantno su opadale, s procijenjenim godišnjim postotkom promjene (engl, EAPC) od -3,2% za muškarce i -2,8% za žene. Stope mortaliteta kod muškaraca porasle su, s EAPC-om od -5,0% od 1988-1995 i -2,5% od 1995-2008. Stope mortaliteta kod žena su se smanjile, s EAPC-om od -3,2% tijekom čitavog razdoblja. Za kolorektalni karcinom kod muškaraca, analiza uz pomoć točaka spajanja pokazala je trend porasta kako incidencije (EAPC 2,9%) tako i mortaliteta (EAPC 2,1%). Kod žena, porast incidencije nije bio značajan, ali je prosječni godišnji postotak promjene mortaliteta u zadnjih 10 godina značajno porastao za 1,1%. ----- Zaključak Trendovi incidencije i mortaliteta od karcinoma želuca u Hrvatskoj slični su ostalim europskim državama, dok još uvijek rastući trendovi mortaliteta od kolorektalnog karcinoma ukazuju na potrebu za učinkovitijom prevencijom i liječenjem.

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