Incidence and mortality trends of melanoma in Croatia, 1988-2008

Barbarić, Jelena and Znaor, Ariana (2012) Incidence and mortality trends of melanoma in Croatia, 1988-2008. Croatian Medical Journal, 53 (2). pp. 135-140. ISSN 0353-9504

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Abstract

AIM: To analyze melanoma incidence and mortality trends in Croatia 1988-2008, compare them with the trends in other populations, and identify possible changes in the trends. ----- METHODS: Incidence data were obtained from the Croatian National Cancer Registry and the mortality data from the Croatian Bureau of Statistics. United Nations population estimates were used for calculating the age-specific rates. Age-standardized rates were calculated by the direct standardization method, using the world standard population as a reference. To estimate incidence and mortality trends, we performed joinpoint regression analysis. ----- RESULTS: A significantly increasing incidence trend, with estimated annual percent change (EAPC) of 5.9% for men and 5.6% for women, was observed over the whole 21-year period and no additional joinpoints were identified. The overall incidence increase between the first and the last five-year period was 149% for men and 130% for women. Significant increase in the mortality trend was observed, with EAPC of 3.0% for men and 2.4% for women. No joinpoints were identified. The overall increase in mortality between the first and the last five-year period was 45% for men and 50% for women. ----- CONCLUSION: Melanoma rates in Croatia are steadily and markedly rising, with similar trends to those in the countries with lower/intermediate incidence. It is important to further investigate the more specific causes of the increasing trends, as well as to implement effective public policies targeting the melanoma burden.

Abstract in Croatian

Trendovi incidencije i mortaliteta od melanoma u Hrvatskoj, 1988.-2008. ----- Cilj Analizirati trendove incidencije i mortaliteta od melanoma u Hrvatskoj, 1988.-2008., usporediti ih s trendovima u ostalim populacijama, i identificirati potencijalne promjene u trendovima. ----- Postupci Podaci o incidenciji prikupljeni su iz Hrvatskog registra za rak, a podaci o mortalitetu iz Hrvatskog zavoda za statistiku. Dobno-specifične stope izračunate su pomoću populacijskih procjena Ujedinjenih naroda. Dobno-standardizirane stope izračunate su metodom izravne standardizacije, koristeći svjetsku standardnu populaciju. Za procjenu trendova incidencije i mortaliteta proveli smo regresijsku analizu uz pomoć točaka spajanja (engl, joinpoint regression analysis). ----- Rezultati Trend značajnog porasta incidencije, s procijenjenim godišnjim postotkom promjene (engl, EAPC) od 5,9% za muškarce i 5,6% za žene, bio je stabilan u čitavom 21-godišnjem razdoblju i nisu nađene dodatne točka spajanja. Ukupni porast incidencije između prvog i zadnjeg petogodišnjeg razdoblja bio je 149% za muškarce i 130% za žene. Primijećen je i značajan porast u trendu mortaliteta, s EAPC-om od 3,0% za muškarce i 2,4% za žene. Točke spajanja nisu identificirane. Ukupni porast mortaliteta između prvog i zadnjeg petogodišnjeg razdoblja bio je 45% za muškarce i 50% za žene. ----- Zaključak Stope mortaliteta od melanoma u Hrvatskoj kontinuirano i značajno rastu, slično onima u ostalim zemljama s niskom/umjerenom incidencijom. Potrebno je dodatno istražiti specifične uzroke rastućih trendova te uvesti učinkovite javno-zdravstvene mjere za smanjenje tereta melanoma.

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