Breast and gynecological cancers in Croatia, 1988-2008

Kelava, Iva and Tomičić, Karlo and Kokić, Marina and Ćorušić, Ante and Planinić, Pavao and Kirac, Iva and Murgić, Jure and Kuliš, Tomislav and Znaor, Ariana (2012) Breast and gynecological cancers in Croatia, 1988-2008. Croatian Medical Journal, 53 (2). pp. 100-8. ISSN 0353-9504

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Abstract

AIM: To analyze and interpret incidence and mortality trends of breast and ovarian cancers and incidence trends of cervical and endometrial cancers in Croatia for the period 1988-2008. ----- METHODS: Incidence data were obtained from the Croatian National Cancer Registry. Themortality data were obtained from the World Health Organization (WHO) mortality database. Trends of incidence and mortality were analysed by joinpoint regression analysis. ----- RESULTS: Joinpoint analysis showed an increase in the incidence of breast cancer with estimated annual percent of change (EAPC) of 2.6% (95% confidence interval [CI], 1.9 to 3.4). The mortality rate was stable, with the EAPC of 0.3%. Endometrial cancer showed an increasing incidence trend, with EAPC of 0.8% (95% CI, 0.2 to 1.4), while cervical cancer showed a decreasing incidence trend, with EAPC of -1.0 (95% CI, -1.6 to -0.4). Ovarian cancer incidence showed three trends, but the average annual percent change (AAPC) for the overall period was not significant, with a stable trend of 0.1%. Ovarian cancer mortality was increasing since 1992, with EAPC of 1.2% (95% CI, 0.4 to 1.9), while the trend for overall period was stable with AAPC 0.1%. ----- CONCLUSION: Incidence trends of breast, endometrial, and ovarian cancers in Croatia 1988-2008 are similar to the trends observed in most of the European countries, while the modest decline in cervical cancer incidence and lack of decline in breast cancer mortality suggest suboptimal cancer prevention and control.

Abstract in Croatian

Rak dojke i ginekološki rak u Hrvatskoj, 1988.-2008. ----- Cilj Analizirati i interpretirati trendove incidencije i mortaliteta od raka dojke i jajnika i trendove incidencije raka vrata maternice i endometrija u Hrvatskoj u razdoblju 1988.-2008. ----- Postupci Podaci o incidenciji prikupljeni su iz Hrvatskog registra za rak, a podaci o mortalitetu od raka dojke iz baze podataka o mortalitetu Svjetske zdravstvene organizacije. Trendovi incidencije i mortaliteta od raka dojke analizirani su regresijskom analizom uz pomoć točaka spajanja (engl, joinpoint regression analysis). ----- Rezultati Analiza uz pomoć točaka spajanja pokazala je porast incidencije raka dojke s procijenjenim godišnjim postotkom promjene (engl, EAPC) od 2,6% (95% raspon pouzdanosti [engl, CI], 1,9 do 3,4). Stopa mortaliteta bila je stabilna, s EAPC-om od 0,3% (95% CI, -0,6 do 0,0). Rak endometrija pokazao je trend porasta, s EAPC-om od 0,8% (95% CI, 0,2 do 1,4), dok je rak vrata maternice pokazao pad incidencije, s EAPC-om od -1,0 (95% CI, -1,6 do -0,4). Incidencija raka jajnika pokazala je tri trenda, ali prosječni godišnji postotak promjene (AAPC) za čitavo razdoblje nije bio značajan, sa stabilnim trendom od 0,1%. Mortalitet od raka jajnika rastao je od 1992., s EAPC-om od 1,2% (95% CI, 0,4 do 1,9), dok je trend za čitavo razdoblje bio stabilan s AAPC-om od 0,1%. ----- Zaključak Trendovi incidencije raka dojke, endometrija i jajnika u Hrvatskoj u razdoblju 1988.-2008. slični su trendovima u ostalim europskim zemljama, dok slab pad incidencije raka vrata maternice i izostanak pada mortaliteta od raka dojke ukazuju na nedostatnu prevenciju i kontrolu tih bolesti.

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