Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

Grazio, Simeon and Kusić, Zvonko and Cvijetić, Selma and Grubišić, Frane and Balenović, Antonija and Nemčić, Tomislav and Matijević-Mikelić, Valentina and Punda, Marija and Sieper, Joachim (2012) Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study. Rheumatology International, 32 (9). pp. 2801-2808. ISSN 0172-8172

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    English abstract

    In ankylosing spondylitis, inflammatory activity probably plays a key role in the pathophysiology of bone loss. The aim of the study was to investigate the relationship of bone mineral density (BMD) at the lumbar spine and hip region with some measures of disease activity and functional ability in patients with ankylosing spondylitis. In 80 patients with established ankylosing spondylitis, disease activity and functional ability were determined by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Spinal pain and patient global health were assessed using horizontal visual analog scale. BMD was measured by dual-energy X-ray absorptiometry. There was a significant negative correlation of bone density T scores with acute-phase reactants (i.e., patients with lower T scores had higher level of CRP and ESR). That relationship was reflected more reliably at proximal femur sites than at the lumbar spine. There were also significant differences in ESR, BASDAI, BASFI, spinal pain and global health between three groups of patients according to WHO classification of osteoporosis (normal, osteopenic and osteoporotic). Significantly, more patients with osteopenia at the lumbar spine had lower BASDAI index than those with normal BMD (P = 0.030). Our results indicate an association of low BMD with high disease activity in patients with AS. Femoral BMD seems to be more associated with disease activity and functional ability than lumbar spine BMD.

    Item Type: Article
    Divisions: Katedra za radiologiju i opću kliničku onkologiju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Grazio, Simeon
    Kusić, Zvonko
    Cvijetić, Selma
    Grubišić, Frane
    Balenović, Antonija
    Nemčić, Tomislav
    Matijević-Mikelić, Valentina
    Punda, Marija
    Sieper, Joachim
    Date: September 2012
    Date Deposited: 21 Nov 2012 13:56
    Last Modified: 21 Nov 2012 13:56
    Subjects: /
    Related URLs:
    URI: http://medlib.mef.hr/id/eprint/1706

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