Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty

Buljan, Melita and Nemet, Damir and Golubić-Ćepulić, Branka and Bićanić, Goran and Tripković, Branko and Delimar, Domagoj (2012) Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty. International Orthopaedics, 36 (4). pp. 703-709. ISSN 0341-2695

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Abstract

PURPOSE: Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA). ----- METHODS: Prospective randomised trials in which erythropoietin 15,000 IU was administered intravenously twice a week or 30,000 IU once a week (total 90,000 IU) combined with ferrous II sulphate (Ferro-Gradumet 2) orally and compared with Ferro-Gradumet 2 alone. ----- RESULTS: Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients. ----- CONCLUSION: We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.

Item Type: Article
MeSH: Administration, Oral ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/methods ; Blood Transfusion, Autologous/methods ; Drug Administration Schedule ; Drug Therapy, Combination ; Erythropoietin/administration & dosage ; Female ; Ferrous Compounds/administration & dosage ; Hemoglobins/metabolism ; Humans ; Injections, Intravenous ; Male ; Middle Aged ; Osteoarthritis, Hip/metabolism ; Osteoarthritis, Hip/surgery ; Preoperative Care ; Recombinant Proteins
Departments: Katedra za internu medicinu
Katedra za ortopediju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Buljan, MelitaUNSPECIFIED
Nemet, DamirUNSPECIFIED
Golubić-Ćepulić, BrankaUNSPECIFIED
Bićanić, GoranUNSPECIFIED
Tripković, BrankoUNSPECIFIED
Delimar, DomagojUNSPECIFIED
Date: April 2012
Date Deposited: 31 Oct 2012 10:23
Last Modified: 31 Oct 2012 10:27
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1657

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