Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty

Buljan, Melita and Nemet, Damir and Golubić-Ćepulić, Branka and Bićanić, Goran and Tripković, Branko and Delimar, Domagoj (2012) Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty. International Orthopaedics, 36 (4). pp. 703-709. ISSN 0341-2695

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Official URL: https://doi.org/10.1007/s00264-011-1367-7

Abstract

PURPOSE: Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA). ----- METHODS: Prospective randomised trials in which erythropoietin 15,000 IU was administered intravenously twice a week or 30,000 IU once a week (total 90,000 IU) combined with ferrous II sulphate (Ferro-Gradumet 2) orally and compared with Ferro-Gradumet 2 alone. ----- RESULTS: Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients. ----- CONCLUSION: We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.

Item Type:

Article

MeSH:

Administration, Oral ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/methods ; Blood Transfusion, Autologous/methods ; Drug Administration Schedule ; Drug Therapy, Combination ; Erythropoietin/administration & dosage ; Female ; Ferrous Compounds/administration & dosage ; Hemoglobins/metabolism ; Humans ; Injections, Intravenous ; Male ; Middle Aged ; Osteoarthritis, Hip/metabolism ; Osteoarthritis, Hip/surgery ; Preoperative Care ; Recombinant Proteins

Departments:

Katedra za internu medicinu
Katedra za ortopediju

Depositing User:

Marijan Šember

Status:

Published

Creators:

Creators	Email
Buljan, Melita	UNSPECIFIED
Nemet, Damir	UNSPECIFIED
Golubić-Ćepulić, Branka	UNSPECIFIED
Bićanić, Goran	UNSPECIFIED
Tripković, Branko	UNSPECIFIED
Delimar, Domagoj	UNSPECIFIED

Date:

April 2012

Date Deposited:

31 Oct 2012 10:23

Last Modified:

08 Jul 2020 09:28

Subjects:

Related URLs:

Publisher

URI:

http://medlib.mef.hr/id/eprint/1657

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