Uloga rezultata analize mikrosatelitskih lokusa u transplantaciji hematopoetskih matičnih stanica [The role of the microsatellite analysis results in the hematopoietic stem cell transplatation]

Štingl, Katarina (2009) Uloga rezultata analize mikrosatelitskih lokusa u transplantaciji hematopoetskih matičnih stanica [The role of the microsatellite analysis results in the hematopoietic stem cell transplatation]. PhD thesis, Sveučilište u Zagrebu.

[img]
Preview
PDF
Download (1MB) | Preview

Abstract

Analysis of microsatellites was performed to evaluate their role in the hematopoietic stem cell transplantation program. The applicability in the distinguishing of recipient and donor cells during the chimerism following after transplantation was investigated for 10 non-HLA loci. Conversely, the importance of recipient/donor matching for 13 HLA microsatellites in the unrelated transplantation outcome and their role in survival of patients with related donor was investigated. The study included 150 healthy, unrelated subjects and 120 patients who underwent transplantation and their donors. Results of population studies of all microsatellites have not revealed any statistically significant difference between Croatian and other European populations. The investigation showed that non-HLA microsatellite analysis is a method of choice for chimerism determination; all analyzed non-HLA microsatellites satisfied informativeness criteria for this procedure. Furthermore, results indicated that chimerism status is important in transplantation outcome prediction. No correlation was found between a better transplantation outcome and recipient/donor matching for any of the tested HLA microsatellites, but an influence of the TNFa microsatellite on patient survival after transplantation was observed. In conclusion, the microsatellite analysis has an important role in transplantation outcome improvement by enabling timely treatment interventions and indicating patients with a higher risk for developing post-transplantation complications.

Abstract in Croatian

Analiza mikrosatelita provedena je u svrhu ispitivanja njihove uloge u transplantaciji hematopoetskih matičnih stanica. Prvi dio istraživanja ispitivao je mogućnost primjene 10 lokusa non-HLA u razlikovanju stanica primatelja i davatelja za praćenje kimerizma nakon transplantacije. Drugi dio istraživanja obuhvatio je ispitivanje raznolikosti 13 mikrosatelita HLA, važnost njihove podudarnosti u paru primatelj/nesrodni davatelj za ishod transplantacije te njihovu ulogu u preživljavanju bolesnika koji su primili transplantat od srodnog davatelja. Istraživanje je obuhvatilo 150 zdravih, nesrodnih ispitanika i 120 ispitanika liječenih transplantacijom te njihove davatelje. Rezultati populacijskih istraživanja mikrosatelita non-HLA i mikrosatelita HLA nisu ukazali na statistički značajne razlike između hrvatske i evropskih populacija. Istraživanje je pokazalo da je analiza mikrosatelita non-HLA metoda izbora za određivanje kimerizma te da svi analizirani lokusi zadovoljavaju kriterije informativnosti za uključivanje u postupak praćenja kimerizma. Rezultati također upućuju da je analiza kimerizma važna za predviđanje ishoda transplantacije. Nije pronađena povezanost podudarnosti para primatelj/nesrodni davatelj s boljim ishodom transplantacije za niti jedan od analiziranih mikrosatelita HLA. Unutar parova primatelj/srodni davatelj uočen je utjecaj mikrosatelita TNFa na preživljavanje ispitanika nakon transplantacije. Zaključno, analiza mikrosatelita ima značajnu ulogu u poboljšanju ishoda transplantacije omogućujući pravodobne intervencije u liječenju te ukazujući na bolesnike s povećanim rizikom za razvoj komplikacija nakon transplantacije.

Item Type: Thesis (PhD)
Mentors:
Mentor
Grubić, Zorana
Departments: Katedra za urologiju
Depositing User: dr.med. Helena Markulin
University: Sveučilište u Zagrebu
Institution: Medicinski fakultet
Number of Pages: 140
Status: Unpublished
Creators:
CreatorsEmail
Štingl, KatarinaUNSPECIFIED
Date: 22 September 2009
Date Deposited: 19 Nov 2012 12:54
Last Modified: 19 Nov 2012 12:54
Subjects: WH Hemic and Lymphatic Systems > WH 120-540 Hematologic Diseases. Immunologic Factors. Blood Banks
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/1656

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year