Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking

Babić, Mirjana and Nedić, Gordana and Muck-Šeler, Dorotea and Borovečki, Fran and Pivac, Nela (2012) Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. Neuroscience Letters, 520 (1). pp. 67-70. ISSN 0304-3940

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Nicotine addiction, related to cigarette smoking, develops as a product of the complex interactions between social, environmental and genetic factors. Genes encoding the components of the dopaminergic system are thought to be associated with smoking. Literature data showed not only an association, but also a lack of association between variable number of tandem repeats (VNTR) polymorphism located in the third exon of dopamine D4 receptor (DRD4) gene and smoking. Repetitive sequence of DRD4 VNTR is 48 bp long and maximum 11 tandem copies were reported in humans. Presence of alleles with 6 and more repeats (i.e. long alleles) was associated with greater tendency to novelty seeking and addictive behaviors than the presence of 5 and less alleles (short alleles). The aim of this study was to determine the association between VNTR in DRD4 gene and present smoking status in ethnically homogenous Caucasian population from the Eastern European (Croatian) origin. Genotyping was done in 565 healthy subjects, 511 men and 54 women, respectively, who were subdivided into 176 smokers and 389 nonsmokers. Logistic regression analyses, adjusted for age and sex, revealed the lack of significant (p>0.05) effect of the 4/4, 4/7 and 7/7 genotypes, or carriers of the long and short allele, or all genotypes of the DRD4 VNTR on smoking status. The results of this study failed to confirm the hypothesis that long allele of the DRD4 VNTR is associated with smoking status in Caucasian subjects.

Item Type: Article
MeSH: Adult ; European Continental Ancestry Group ; Female ; Genetic Association Studies ; Humans ; Logistic Models ; Male ; Minisatellite Repeats ; Polymorphism, Genetic ; Receptors, Dopamine D4/genetics ; Smoking/genetics
Departments: Katedra za anatomiju i kliničku anatomiju
Depositing User: Marijan Šember
Status: Published
Muck-Šeler, DoroteaUNSPECIFIED
Borovečki, FranUNSPECIFIED
Date: 27 June 2012
Date Deposited: 29 Oct 2012 12:25
Last Modified: 29 Oct 2012 12:28
Subjects: /
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