Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking

Babić, Mirjana and Nedić, Gordana and Muck-Šeler, Dorotea and Borovečki, Fran and Pivac, Nela (2012) Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking. Neuroscience Letters, 520 (1). pp. 67-70. ISSN 0304-3940

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    English abstract

    Nicotine addiction, related to cigarette smoking, develops as a product of the complex interactions between social, environmental and genetic factors. Genes encoding the components of the dopaminergic system are thought to be associated with smoking. Literature data showed not only an association, but also a lack of association between variable number of tandem repeats (VNTR) polymorphism located in the third exon of dopamine D4 receptor (DRD4) gene and smoking. Repetitive sequence of DRD4 VNTR is 48 bp long and maximum 11 tandem copies were reported in humans. Presence of alleles with 6 and more repeats (i.e. long alleles) was associated with greater tendency to novelty seeking and addictive behaviors than the presence of 5 and less alleles (short alleles). The aim of this study was to determine the association between VNTR in DRD4 gene and present smoking status in ethnically homogenous Caucasian population from the Eastern European (Croatian) origin. Genotyping was done in 565 healthy subjects, 511 men and 54 women, respectively, who were subdivided into 176 smokers and 389 nonsmokers. Logistic regression analyses, adjusted for age and sex, revealed the lack of significant (p>0.05) effect of the 4/4, 4/7 and 7/7 genotypes, or carriers of the long and short allele, or all genotypes of the DRD4 VNTR on smoking status. The results of this study failed to confirm the hypothesis that long allele of the DRD4 VNTR is associated with smoking status in Caucasian subjects.

    Item Type: Article
    MeSH: Adult ; European Continental Ancestry Group ; Female ; Genetic Association Studies ; Humans ; Logistic Models ; Male ; Minisatellite Repeats ; Polymorphism, Genetic ; Receptors, Dopamine D4/genetics ; Smoking/genetics
    Divisions: Katedra za anatomiju i kliničku anatomiju
    Depositing User: Marijan Šember
    Status: Published
    Babić, Mirjana
    Nedić, Gordana
    Muck-Šeler, Dorotea
    Borovečki, Fran
    Pivac, Nela
    Date: 27 June 2012
    Date Deposited: 29 Oct 2012 13:25
    Last Modified: 29 Oct 2012 13:28
    Subjects: /
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