Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Health-related quality of life and fatigue in patients with adrenal incidentaloma

Kaštelan, Darko and Džubur, Fedja and Dušek, Tina and Poljičanin, Tamara and Crnčević-Orlić, Željka and Kraljević, Ivana and Solak, Mirsala and Benčević, Tanja and Aganović, Izet and Knežević, Nikola and Kaštelan, Željko and Koršić, Mirko (2011) Health-related quality of life and fatigue in patients with adrenal incidentaloma. Endocrine, 40 (1). pp. 84-89. ISSN 1355-008X

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    English abstract

    The objective of the present study was to examine several dimensions of quality of life (QoL) and fatigue in patients with adrenal incidentaloma. This was a case-control study designed to analyze patient outcomes using three validated generic QoL questionnaires, EQ-5D, SF-36, and MFI-20, the results of which were compared to those obtained for age- and sex-matched controls. The study population comprised 139 consecutive patients with nonfunctioning adrenal masses (104 females, 35 males; age 59.1 ± 10.8) and 139 age- and sex-matched controls. Reduced QoL was found in patients with adrenal incidentaloma as compared to controls. Dimensions of QoL that were notably affected included mobility (P = 0.03), performance of usual activities (P = 0.002), and anxiety/depression (P = 0.04) as evaluated using the EQ-5D; physical functioning (P < 0.001), physical role (P < 0.001), general health (P < 0.001), vitality (P = 0.001), social functioning (P = 0.001), and emotional role (P < 0.001) as evaluated using the SF-36; and physical fatigue (P = 0.04) as assessed using the MFI-20 questionnaire. In addition, perceived health on a visual analogue scale was also significantly lower in patients than in controls (64.8 ± 19.2 vs. 77.1 ± 15.1; P < 0.001). Patients with adrenal incidentaloma reported reduced QoL and a higher level of physical fatigue compared to age- and sex-matched controls. This subject will benefit from further studies comparing QoL outcomes of laparoscopic adrenalectomy versus no treatment in patients with adrenal incidentaloma.

    Item Type: Article
    MeSH: Activities of Daily Living/psychology ; Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/physiopathology ; Adrenal Gland Neoplasms/psychology ; Aged ; Case-Control Studies ; Depression/epidemiology ; Depression/etiology ; Depression/physiopathology ; Fatigue/epidemiology ; Fatigue/etiology ; Fatigue/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Quality of Life/psychology ; Questionnaires
    Divisions: Katedra za internu medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Kaštelan, Darko
    Džubur, Fedja
    Dušek, Tina
    Poljičanin, Tamara
    Crnčević-Orlić, Željka
    Kraljević, Ivana
    Solak, Mirsala
    Benčević, Tanja
    Aganović, Izet
    Knežević, Nikola
    Kaštelan, Željko
    Koršić, Mirko
    Date: August 2011
    Date Deposited: 01 Jun 2012 13:49
    Last Modified: 01 Jun 2012 13:49
    Subjects: /
    Related URLs:
    URI: http://medlib.mef.hr/id/eprint/1602

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