Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents.

Podobnik, Josip and Foller Podobnik, Iris and Grgić, Neda and Marčinko, Darko and Pivac, Nela (2012) The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents. Psychopharmacology, 220 (3). pp. 639-641. ISSN 0033-3158

[img]
Preview
PDF
Download (237Kb) | Preview

    English abstract

    Rationale Atypical antipsychotics are frequently prescribed for psychotic and mood disorders in youth, and for symptoms of depression, aggression, irritability and suicidal tendencies, which are associated with subsequent development of borderline personality disorders (BPD). ----- Objectives This study evaluated the effects of 24-weeks of add-on treatment with quetiapine to selective serotonin reuptake inhibitors (SSRIs) in young people with pronounced symptoms of depression, aggression, irritability and suicidal tendencies. ----- Methods In an open-label 24-weeks trial, 22 SSRI-treatment resistant patients (age range 9-18 years) with developing BPD were treated with quetiapine (75-600 mg/day) in combination with SSRIs. Symptoms of depression, aggression, irritability and suicidal tendencies were rated with the Overt Aggression Scale Modified (OAS-M), Kutcher Adolescent Depression Scale (KADS-6) and Children Global Assessment Scale (C-GAS) before and after 4-24 weeks of treatment. ----- Results Quetiapine induced significant (p<0.001) improvement after 4-24 weeks, with a modest but significant increase in the C-GAS total scores (i.e. children’s general clinical status), and a significant reduction of the total scores in OAS-M, KADS-6 and OAS-M subscales for aggression, irritability and suicidality. There were no discontinuations for adverse effects. Conclusions These preliminary results suggest that quetiapine addition to SSRIs treatment significantly reduced symptoms of depression, aggression, irritability and suicidal tendencies in young people with developing BPD.

    Item Type: Article
    Divisions: Katedra za psihijatriju i psihološku medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Podobnik, Josip
    Foller Podobnik, Iris
    Grgić, Neda
    Marčinko, Darko
    Pivac, Nela
    Date: April 2012
    Date Deposited: 29 May 2012 13:55
    Last Modified: 29 May 2012 13:55
    Subjects: /
    Related URLs:
    URI: http://medlib.mef.hr/id/eprint/1598

    Actions (login required)

    View Item

    Document Downloads

    More statistics for this item...