Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma

Ulamec, Monika and Džombeta, Tihana and Čupić, Hrvoje and Leniček, Tanja and Tomas, Davor and Krušlin, Božo (2012) Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma. Pathology & Oncology Research, 18 (2). pp. 365-370. ISSN 1219-4956

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    English abstract

    Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous tissue compared to adjacent normal prostatic tissue. On the other hand, the number of lymph vessels in tumorous tissue was significantly higher than the number of lymph vessels mimicking periacinar retractions. Overall, the number of lymph vessels mimicking periacinar clefts was particularly low. These results are in accordance with our previous studies, which had shown that periacinar clefting appears due to lack of basal cells and stromal changes around tumorous acini. Also, these results support our hypothesis that retractions do not represent lymph vessels but should be considered a distinct entity, which is proven to be helpful both as diagnostic and predictive factor.

    Item Type: Article
    Divisions: Katedra za patologiju
    Depositing User: Marijan Šember
    Status: Published
    Ulamec, Monika
    Džombeta, Tihana
    Čupić, Hrvoje
    Leniček, Tanja
    Tomas, Davor
    Krušlin, Božo
    Date: April 2012
    Date Deposited: 11 May 2012 13:27
    Last Modified: 11 May 2012 13:27
    Subjects: /
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