Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Renal artery changes in patients with primary renal cell carcinoma

Tomić, Karla and Tomas, Davor and Tomašković, Igor and Kos, Marina and Belicza, Mladen and Krušlin, Božo (2006) Renal artery changes in patients with primary renal cell carcinoma. Virchows Archiv, 448 (1). pp. 24-28. ISSN 0945-6317 (Print) 1432-2307 (Electronic)

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    English abstract

    Arterial fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic, occlusive condition of the systemic arteries, most frequently affecting renal arteries. Renal cell carcinoma (RCC) might be associated with arterial hypertension; however, there are no data in the literature regarding the relationship between RCC and associated renal artery changes. We analyzed a consecutive series of 57 (35 male and 22 female) patients aging from 35 to 79 years (mean 58.9 years) who underwent nephrectomy due to RCC in the year 2003. The patients had RCC measuring from 2 to 16 cm (mean 7.1 cm). Specimens were routinely fixed, embedded in paraffin, cut, and stained with hematoxylin and eosin, Mallory trichrome method, and orcein. Renal arteries of 26 patients (20 male, 6 female) showed no changes. In these patients, RCC measured 2.5-11 cm in largest diameter (mean 6.6 cm). In 24 patients (10 male, 14 female), renal arteries showed FMD. RCCs in these patients measured between 2 and 16 cm (mean 8.0 cm). Seven patients had atherosclerotic changes in renal arteries. In this series, FMD was found in a significant proportion of patients with RCC, mainly in women. The cause of such changes and their relationship with RCC and systemic hypertension should be further analyzed.

    Item Type: Article
    MeSH: Carcinoma , Renal Cell - blood supply - pathology ; Fibromuscular Dysplasia - epidemiology - pathology ; Kidney Neoplasms - blood supply - pathology ; Renal Artery - pathology ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged
    Divisions: Katedra za patologiju
    Depositing User: Lea Škorić
    Status: Published
    Tomić, Karla
    Tomas, Davor
    Tomašković, Igor
    Kos, Marina
    Belicza, Mladen
    Krušlin, Božo
    Date: January 2006
    Date Deposited: 05 Dec 2006
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
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