Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma

Tomas, Davor and Ulamec, Monika and Hudolin, Tvrtko and Bulimbašić, Stela and Belicza, Mladen and Krušlin, Božo (2006) Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma. Prostate Cancer and Prostatic Diseases, 9 (4). pp. 414-419. ISSN 1365-7852 (Print) 1476-5608 (Electronic)

Preview

PDF
Download (388Kb) | Preview

Official URL: http://www.nature.com/pcan/journal/v9/n4/abs/45008...

English abstract

The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoural tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.

Item Type:

Article

MeSH:

Adenocarcinoma - metabolism - pathology - surgery ; Laminin - metabolism ; Neoplasms, Muscle Tissue - metabolism - pathology - surgery ; Prostatic Neoplasms - metabolism - pathology - surgery ; Stromal Cells - metabolism - pathology ; Tenascin - metabolism ; Actins - metabolism ; Aged ; Aged, 80 and over ; Case-Control Studies ; Desmin - metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging ; Prostatectomy ; Prostatic Hyperplasia - metabolism - pathology - surgery ; Treatment Outcome ; Tumor Markers, Biological - metabolism ; Vimentin - metabolism

Divisions:

Katedra za patologiju

Depositing User:

Lea Škorić

Status:

Published

Creators: