Tomas, Davor and Ulamec, Monika and Hudolin, Tvrtko and Bulimbašić, Stela and Belicza, Mladen and Krušlin, Božo
Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma.
Prostate Cancer and Prostatic Diseases, 9 (4).
ISSN 1365-7852 (Print) 1476-5608 (Electronic)
The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoural tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.
||Adenocarcinoma - metabolism - pathology - surgery ; Laminin - metabolism ; Neoplasms, Muscle Tissue - metabolism - pathology - surgery ; Prostatic Neoplasms - metabolism - pathology - surgery ; Stromal Cells - metabolism - pathology ; Tenascin - metabolism ; Actins - metabolism ; Aged ; Aged, 80 and over ; Case-Control Studies ; Desmin - metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging ; Prostatectomy ; Prostatic Hyperplasia - metabolism - pathology - surgery ; Treatment Outcome ; Tumor Markers, Biological - metabolism ; Vimentin - metabolism
||Katedra za patologiju
||16 Oct 2007
||23 Sep 2011 16:09
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