3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia

Vitart, Veronique and Biloglav, Zrinka and Hayward, Caroline and Janićijević, Branka and Smolej-Narančić, Nina and Barać, Lovorka and Peričić, Marijana and Martinović-Klarić, Irena and Škarić-Jurić, Tatjana and Barbalić, Maja and Polašek, Ozren and Kolčić, Ivana and Carothers, Andrew and Rudan, Pavao and Hastie, Nick and Wright, Alan and Campbell, Harry and Rudan, Igor (2006) 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia. European journal of human genetics, 14 (4). pp. 478-487. ISSN 1018-4813 (Print) 1476-5438 (Electronic)

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Abstract

Communities with increased shared ancestry represent invaluable tools for genetic studies of complex traits. '1001 Dalmatians' research program collects biomedical information for genetic epidemiological research from multiple small isolated populations ('metapopulation') in the islands of Dalmatia, Croatia. Random samples of 100 individuals from 10 small island settlements (n<2000 inhabitants) were collected in 2002 and 2003. These island communities were carefully chosen to represent a wide range of distinct and well-documented demographic histories. Here, we analysed their genetic make-up using 26 short tandem repeat (STR) markers, at least 5 cM apart. We found a very high level of differentiation between most of these island communities based on Wright's fixation indexes, even within the same island. The model-based clustering algorithm, implemented in STRUCTURE, defined six clusters with very distinct genetic signatures, four of which corresponded to single villages. The extent of background LD, assessed with eight linked markers on Xq13-21, paralleled the extent of differentiation and was also very high in most of the populations under study. For each population, demographic history was characterised and 12 'demographic history' variables were tentatively defined. Following stepwise regression, the demographic history variable that most significantly predicted the extent of LD was the proportion of locally born grandparents. Strong isolation and endogamy are likely to be the main forces maintaining this highly structured overall population.

Item Type: Article
Departments: Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
Depositing User: Lea Škorić
Status: Published
Creators:
CreatorsEmail
Vitart, VeroniqueUNSPECIFIED
Biloglav, ZrinkaUNSPECIFIED
Hayward, CarolineUNSPECIFIED
Janićijević, BrankaUNSPECIFIED
Smolej-Narančić, NinaUNSPECIFIED
Barać, LovorkaUNSPECIFIED
Peričić, MarijanaUNSPECIFIED
Martinović-Klarić, IrenaUNSPECIFIED
Škarić-Jurić, TatjanaUNSPECIFIED
Barbalić, MajaUNSPECIFIED
Polašek, OzrenUNSPECIFIED
Kolčić, IvanaUNSPECIFIED
Carothers, AndrewUNSPECIFIED
Rudan, PavaoUNSPECIFIED
Hastie, NickUNSPECIFIED
Wright, AlanUNSPECIFIED
Campbell, HarryUNSPECIFIED
Rudan, IgorUNSPECIFIED
Date: April 2006
Date Deposited: 11 Dec 2006
Last Modified: 23 Sep 2011 16:09
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/154

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