Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

A dopamine agonist, pramipexole, and cognitive functions in Parkinson's disease

Relja, Maja and Klepac, Nataša (2006) A dopamine agonist, pramipexole, and cognitive functions in Parkinson's disease. Journal of the Neurological Sciences, 248 (1-2). pp. 251-254. ISSN 0022-510X (Print)

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    English abstract

    The cognitive performance of 55 non-demented idiopathic Parkinson's disease (PD) patients treated with levodopa alone or receiving dopamine agonist pramipexole as add-on therapy to levodopa was evaluated in the present study during 6 months of treatment. Neuropsychological tests were administered two times. In the first assessment to differentiate test sensitive to cognitive changes typical for PD control group was also assessed. After 6 months of treatment PD patients were retested only with tests that differentiate them from control group. Compared to controls PD patients showed inferior performance on Stroop Interference test, Trail Making test, letter fluency and Hooper Visual Organization Test. No statistically significant differences between two groups and first and second neuropsychological assessment were found. Present findings indicate that pramipexole as add-on therapy to levodopa is safe in non-demented PD patients in terms of the effect on cognitive performance.

    Item Type: Article
    MeSH: Antiparkinson Agents - pharmacology - therapeutic use ; Benzothiazoles - pharmacology - therapeutic use ; Cognition - drug effects ; Parkinson Disease - drug therapy - physiopathology ; Adult ; Aged ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Levodopa - therapeutic use ; Male ; Middle Aged ; Neuropsychological Tests - statistics & numerical data
    Divisions: Katedra za neurologiju
    Depositing User: Lea Škorić
    Status: Published
    Relja, Maja
    Klepac, Nataša
    Date: October 2006
    Date Deposited: 19 Mar 2007
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
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