Tomas, Davor and Krušlin, Božo and Rogatsch, Hermann and Schäfer, Georg and Belicza, Mladen and Mikuz, Gregor
Different types of atrophy in the prostate with and without adenocarcinoma.
European Urology, 51 (1).
ISSN 0302-2838 (Print)
OBJECTIVES: The purpose of this study was to evaluate, according to a classification proposed by a working group, the extent and type of atrophy lesions in radical prostatectomy specimens obtained from patients with prostatic carcinoma and benign prostatic hyperplasia (BPH), and to compare the prevalence and types of atrophy between two investigated groups. ----- METHODS: Histologic analysis of 1096 slides from 50 patients with carcinoma and 277 slides from 31 patients with BPH was performed to evaluate, according to the new prostatic atrophy classification, the number of foci and type of atrophic lesions. ----- RESULTS: Age, Gleason grade, and TNM showed no significant correlation with the number of proliferative atrophy (PA) and proliferative inflammatory atrophy (PIA) foci (p>0.05). PIA was significantly more frequent in prostates with carcinoma (1.63 vs 1.27 atrophic lesions per slide) (p<0.001), whereas PA displayed an increased frequency in BPH (2.28 vs 0.76 atrophic lesions per slide) (p<0.001). ----- CONCLUSIONS: We confirmed that PA and PIA are common findings in prostates with and without carcinoma, but the question of whether inflammation produces tissue damage and PA or whether some other insult induces the tissue damage and atrophy directly, with inflammation occurring secondarily, is still unresolved.
||Adenocarcinoma - pathology ; Prostate - pathology ; Adult ; Aged ; Atrophy ; Humans ; Male ; Middle Aged ; Prostatectomy ; Prostatic Hyperplasia - pathology
||Katedra za patologiju
||19 Mar 2007
||23 Sep 2011 16:09
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