Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study

Matković, Božica and Juretić, Antonio and Spagnoli, Giulio C. and Šeparović, Viktor and Gamulin, Marija and Šeparović, Robert and Šarić, Nera and Bašić-Koretić, Martina and Novosel, Irena and Krušlin, Božo (2011) Expression of MAGE-A and NY-ESO-1 cancer/testis antigens in medullary breast cancer: retrospective immunohistochemical study. Croatian Medical Journal, 52 (2). pp. 171-177. ISSN 0353-9504

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    English abstract

    AIM: To immunohistochemically evaluate the expression of MAGE-A1, MAGE-A, and NY-ESO-1 cancer/testis (C/T) tumor antigens in medullary breast cancer (MBC) tumor samples and to analyze it in relation to the clinicopathological features. ----- METHODS: This retrospective study included samples from 49 patients: 40 with typical MBC and 9 with atypical MBC. Tumor specimens were obtained from patients operated on in the University Hospital for Tumors and the Sisters of Mercy University Hospital, Zagreb, Croatia, from 1999 to 2005. Standard immunohistochemistry was used on archival paraffin-embedded MBC tissues. ----- RESULTS: MAGE-A1, MAGE-A, and NY-ESO-1 antigens were expressed in 33% (16/49), 33% (16/49), and 22% (11/49) of patients, respectively. No difference between the groups with and without C/T tumor antigen expression in age at diagnosis, tumor size, axillary lymph node metastasis, adjuvant therapy, and HER-2 expression was identified. Significantly more patients died in the MAGE-A-positive group than in the MAGE-A-negative group (P=0.010), whereas a borderline significance was found between MAGE-A1-positive and the MAGE-A1-negative group (P=0.079) and between NY-ESO-1-positive and NY-ESO-1-negative group (P=0.117). Overall survival, as evaluated by the Kaplan-Meier curves, was lower in MAGE-A1- (P=0.031), MAGE-A- (P=0.004), NY-ESO-1-positive groups (P=0.077). ----- CONCLUSION: Expression of C/T antigens may represent a marker of potential prognostic relevance in MBC.

    Item Type: Article
    MeSH: Adult ; Aged ; Aged, 80 and over ; Antigens/genetics ; Antigens/immunology ; Antigens, Neoplasm/analysis ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Breast Neoplasms/immunology ; Carcinoma, Medullary/immunology ; Croatia ; Female ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Immunohistochemistry ; Membrane Proteins/analysis ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Middle Aged ; Neoplasm Proteins/analysis ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Peptide Fragments/analysis ; Peptide Fragments/genetics ; Peptide Fragments/immunology ; Retrospective Studies ; Survival Analysis
    Divisions: Katedra za patologiju
    Katedra za radiologiju i opću kliničku onkologiju
    Depositing User: Marijan Šember
    Status: Published
    Matković, Božica
    Juretić, Antonio
    Spagnoli, Giulio C.
    Šeparović, Viktor
    Gamulin, Marija
    Šeparović, Robert
    Šarić, Nera
    Bašić-Koretić, Martina
    Novosel, Irena
    Krušlin, Božo
    Date: 15 April 2011
    Date Deposited: 23 Jan 2012 12:07
    Last Modified: 23 Jan 2012 12:07
    Subjects: /
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