Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Pharmaceutical principles of acid inhibitors: unmet needs

Krznarić, Željko and Ljubas Kelečić, Dina and Rustemović, Nadan and Vranešić Bender, Darija and Ostojić, Rajko and Markoš, Pave and Scarpignato, Carmelo (2011) Pharmaceutical principles of acid inhibitors: unmet needs. Digestive Diseases, 29 (5). pp. 469-475. ISSN 0257-2753

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    English abstract

    Despite the well-established benefits of currently approved delayed-release proton pump inhibitors (PPIs) in the treatment of acid-related diseases, the unmet needs are still present and although often frustrating, they challenge clinicians. The unmet needs relate to the lack of complete control of acid secretion with oral PPI administration in the management of patients with gastroesophageal symptoms. These substantial groups of patients, who do not respond completely to standard doses of PPIs, are nonresponders, and their lack of response should be considered as PPI failure. Several mechanisms could explain PPI failure: differences in pharmacokinetics, PPI formulation, dosing time and diet, noncompliance, transient lower esophageal sphincter relaxations, esophageal hypersensitivity, and nocturnal acid breakthrough. To increase the quality of life of these patients and avoid multiple medical consultations and unnecessary investigations, we have to go one step forward and use combined therapy or look towards new treatments beyond acid suppression.

    Item Type: Article
    Divisions: Katedra za internu medicinu
    Depositing User: Marijan Šember
    Status: Published
    Krznarić, Željko
    Ljubas Kelečić, Dina
    Rustemović, Nadan
    Vranešić Bender, Darija
    Ostojić, Rajko
    Markoš, Pave
    Scarpignato, Carmelo
    Date: 2011
    Date Deposited: 18 Jan 2012 10:51
    Last Modified: 18 Jan 2012 10:51
    Subjects: /
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