Hyperglycaemia in critical illness is a risk factor for later development of type II diabetes mellitus

Gornik, Ivan and Vujaklija, Ana and Lukić, Edita and Madžarac, Goran and Gašparović, Vladimir (2010) Hyperglycaemia in critical illness is a risk factor for later development of type II diabetes mellitus. Acta Diabetologica, 47 (S1). pp. 29-33. ISSN 0940-5429

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Hyperglycaemia caused by stress and inflammation is common during critical illness. We hypothesised that a latent glucose metabolism disturbance contributes to development of hyperglycaemia and that those patients have increased risk for diabetes. We included patients with sepsis, acute coronary syndrome and acute heart failure with no history of impaired glucose metabolism and divided them in the hyperglycaemia group (glucose ≥ 7.8 mmol/l) and normoglycaemia group. Patients were followed for 5 years. Follow-up was completed for 115 patients in the normoglycaemia group, of which 4 (3.5%) developed type 2 diabetes. In the hyperglycaemia group 51 patients finished follow-up and 8 (15.7%) developed type 2 diabetes. Relative risk in 5-year period for patients with hyperglycaemia was 4.51 for development of type 2 diabetes. Patients with hyperglycaemia during critical illness who are not diagnosed with diabetes before or during the hospitalisation should be considered a population at increased risk for developing diabetes.

Item Type: Article
MeSH: Aged ; Critical Illness ; Croatia/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/metabolism ; Disease Progression ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Hyperglycemia/complications ; Hyperglycemia/metabolism ; Male ; Middle Aged ; Risk Factors ; Triglycerides/metabolism
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Madžarac, GoranUNSPECIFIED
Gašparović, VladimirUNSPECIFIED
Date: December 2010
Date Deposited: 12 Jan 2012 13:14
Last Modified: 12 Jan 2012 13:18
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1430

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