Genes associated with multiple sclerosis: 15 and counting

Habek, Mario and Brinar, Vesna V. and Borovečki, Fran (2010) Genes associated with multiple sclerosis: 15 and counting. Expert Review of Molecular Diagnostics, 10 (7). pp. 857-861. ISSN 1473-7159

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Evaluation of: The International Multiple Sclerosis Genetics Consortium (IMSGC). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun. 11(5), 397-405 (2010). Multiple sclerosis (MS) develops in genetically susceptible populations as a result of environmental exposures, and discovering these genetic and/or environmental factors will provide fundamental new insights into the pathogenesis, diagnosis and treatment of this disabling disease. With the introduction of genome-wide association studies, the number of genes found to be associated with MS has increased rapidly. In all of these genes, in a study by the International Multiple Sclerosis Genetics Consortium, the classic MS risk locus, HLA-DRB1, stood out with remarkably strong statistical significance, but they also identified 12 other loci and/or genes associated with MS. However, all of these alleles have a very modest odds ratio and they explain approximately 3% of the variance in MS risk. Recently, the International Multiple Sclerosis Genetics Consortium provided evidence for three new loci that show significant association at a genome-wide level: RGS1, IL12A and MPHOSPH9/CDK2AP1. In this article, we will review the three newly discovered susceptibility loci and the implications of genome-wide association studies in MS on clinical practice.

Item Type: Article
Departments: Katedra za neurologiju
Depositing User: Marijan Šember
Status: Published
Borovečki, FranUNSPECIFIED
Date: October 2010
Date Deposited: 12 Jan 2012 12:03
Last Modified: 12 Jan 2012 12:03
Subjects: /
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