Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Targeting Fas in osteoresorptive disorders

Kovačić, Nataša and Grčević, Danka and Katavić, Vedran and Lukić, Ivan Krešimir and Marušić, Ana (2010) Targeting Fas in osteoresorptive disorders. Expert Opinion on Therapeutic Targets, 14 (10). pp. 1121-1134. ISSN 1472-8222

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    English abstract

    IMPORTANCE OF THE FIELD: Fas receptor is a mediator of the external apoptotic pathway in many cells and tissues. It is proposed that Fas receptor mediates osteoresorptive effects of estrogen deficiency and local/systemic inflammation. ----- AREAS COVERED IN THIS REVIEW: This review covers the past two decades of research on the expression and function of the Fas-Fas ligand system on bone cells, involvement in the pathogenesis of osteoresorption and potential therapeutic modulation. ----- WHAT THE READER WILL GAIN: We review the structure, biological function and intracellular signaling pathways of the Fas-Fas ligand system emphasizing the role of the non-apoptotic signaling pathways in bone cells, particularly osteoblast differentiation. We also present data on the in vitro expression and function of the Fas-Fas ligand system on osteoblast/osteoclast lineage cells, animal and human studies confirming its involvement in osteoresorptive disorders and potential therapeutic approaches to modulate its function. ----- TAKE HOME MESSAGE: Tissue specific therapeutic approaches need to be established to modify the Fas-Fas ligand system in osteoresorptive disorders as systemic targeting has many side effects. The most promising approach would be to target Fas signaling molecules coupled with osteoblast/osteoclast differentiation pathways, but a precise definition of these targets is still needed.

    Item Type: Article
    MeSH: Animals ; Antigens, CD95/antagonists & inhibitors ; Antigens, CD95/metabolism ; Apoptosis ; Bone Resorption/genetics ; Bone Resorption/physiopathology ; Bone and Bones/physiology ; Bone and Bones/physiopathology ; Cell Differentiation ; Cell Lineage ; Fas Ligand Protein/metabolism ; Fas Ligand Protein/pharmacology ; Fas Ligand Protein/therapeutic use ; Gene Expression ; Humans ; Molecular Targeted Therapy ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoclasts/cytology ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Osteogenesis ; Signal Transduction/drug effects
    Divisions: Katedra za anatomiju i kliničku anatomiju
    Katedra za fiziologiju i imunologiju
    Depositing User: Marijan Šember
    Status: Published
    Kovačić, Nataša
    Grčević, Danka
    Katavić, Vedran
    Lukić, Ivan Krešimir
    Marušić, Ana
    Date: October 2010
    Date Deposited: 12 Jan 2012 12:19
    Last Modified: 12 Jan 2012 12:19
    Subjects: /
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