Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Health-related quality of life among patients with postmenopausal osteoporosis treated with weekly and monthly bisphosphonates

Kaštelan, Darko and Vlak, Tonko and Lozo, Petar and Gradišer, Marina and Mijić, Šime and Nikolić, Tatjana and Miškić, Blaženka and Car, Dolores and Tajsić, Gordana and Dušek, Tina and Jajić, Zrinka and Grubišić, Frane and Poljičanin, Tamara and Bakula, Miro and Džubur, Fedja and Strižak-Ujević, Matilda and Kadojić, Mira and Radman, Maja and Vugrinec, Maja and Kušter, Željka and Pekez, Marijeta and Radović, Endi and Labar, Ljubica and Crnčević-Orlić, Željka and Koršić, Mirko (2010) Health-related quality of life among patients with postmenopausal osteoporosis treated with weekly and monthly bisphosphonates. Endocrine Research, 35 (4). pp. 165-173. ISSN 0743-5800

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    English abstract

    OBJECTIVE: The present study was designed to assess the effect of monthly ibandronate on health-related quality of life (HR-QoL) in patients with postmenopausal osteoporosis previously treated with weekly bisphosphonates. ----- METHODS: HR-QoL was assessed by Euroqol (EQ-5D) and Osteoporosis Targeted Quality of Life (OPTQoL) questionnaires. ----- RESULTS: The EQ-5D questionnaire showed significant improvement associated with ibandronate treatment, occurring in mobility (p < 0.01), usual activity (p < 0.01), pain/discomfort (p < 0.05), and anxiety/depression (p < 0.05). In addition, ibandronate treatment considerably improved patients' perceived health on a visual analog scale (p < 0.001). For the OPTQoL questionnaire, patients reported less physical difficulty (p < 0.001), fewer adaptations in their lives (p < 0.001), and less fear (p < 0.001) with ibandronate than with weekly bisphosphonates. ----- CONCLUSION: The study demonstrated that patients who were transferred from weekly bisphosphonates to a monthly ibandronate experienced improved HR-QoL.

    Item Type: Article
    MeSH: Aged ; Bone Density Conservation Agents/administration & dosage ; Chi-Square Distribution ; Diphosphonates/administration & dosage ; Drug Administration Schedule ; Female ; Humans ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/psychology ; Prospective Studies ; Quality of Life ; Questionnaires
    Divisions: Katedra za fizikalnu medicinu i rehabilitaciju
    Katedra za internu medicinu
    Depositing User: Marijan Šember
    Status: Published
    Kaštelan, Darko
    Vlak, Tonko
    Lozo, Petar
    Gradišer, Marina
    Mijić, Šime
    Nikolić, Tatjana
    Miškić, Blaženka
    Car, Dolores
    Tajsić, Gordana
    Dušek, Tina
    Jajić, Zrinka
    Grubišić, Frane
    Poljičanin, Tamara
    Bakula, Miro
    Džubur, Fedja
    Strižak-Ujević, Matilda
    Kadojić, Mira
    Radman, Maja
    Vugrinec, Maja
    Kušter, Željka
    Pekez, Marijeta
    Radović, Endi
    Labar, Ljubica
    Crnčević-Orlić, Željka
    Koršić, Mirko
    Date: 2010
    Date Deposited: 11 Jan 2012 13:45
    Last Modified: 11 Jan 2012 13:45
    Subjects: /
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