Health-related quality of life among patients with postmenopausal osteoporosis treated with weekly and monthly bisphosphonates

Kaštelan, Darko and Vlak, Tonko and Lozo, Petar and Gradišer, Marina and Mijić, Šime and Nikolić, Tatjana and Miškić, Blaženka and Car, Dolores and Tajsić, Gordana and Dušek, Tina and Jajić, Zrinka and Grubišić, Frane and Poljičanin, Tamara and Bakula, Miro and Džubur, Fedja and Strižak-Ujević, Matilda and Kadojić, Mira and Radman, Maja and Vugrinec, Maja and Kušter, Željka and Pekez, Marijeta and Radović, Endi and Labar, Ljubica and Crnčević-Orlić, Željka and Koršić, Mirko (2010) Health-related quality of life among patients with postmenopausal osteoporosis treated with weekly and monthly bisphosphonates. Endocrine Research, 35 (4). pp. 165-173. ISSN 0743-5800

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Abstract

OBJECTIVE: The present study was designed to assess the effect of monthly ibandronate on health-related quality of life (HR-QoL) in patients with postmenopausal osteoporosis previously treated with weekly bisphosphonates. ----- METHODS: HR-QoL was assessed by Euroqol (EQ-5D) and Osteoporosis Targeted Quality of Life (OPTQoL) questionnaires. ----- RESULTS: The EQ-5D questionnaire showed significant improvement associated with ibandronate treatment, occurring in mobility (p < 0.01), usual activity (p < 0.01), pain/discomfort (p < 0.05), and anxiety/depression (p < 0.05). In addition, ibandronate treatment considerably improved patients' perceived health on a visual analog scale (p < 0.001). For the OPTQoL questionnaire, patients reported less physical difficulty (p < 0.001), fewer adaptations in their lives (p < 0.001), and less fear (p < 0.001) with ibandronate than with weekly bisphosphonates. ----- CONCLUSION: The study demonstrated that patients who were transferred from weekly bisphosphonates to a monthly ibandronate experienced improved HR-QoL.

Item Type: Article
MeSH: Aged ; Bone Density Conservation Agents/administration & dosage ; Chi-Square Distribution ; Diphosphonates/administration & dosage ; Drug Administration Schedule ; Female ; Humans ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/psychology ; Prospective Studies ; Quality of Life ; Questionnaires
Departments: Katedra za fizikalnu medicinu i rehabilitaciju
Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Kaštelan, DarkoUNSPECIFIED
Vlak, TonkoUNSPECIFIED
Lozo, PetarUNSPECIFIED
Gradišer, MarinaUNSPECIFIED
Mijić, ŠimeUNSPECIFIED
Nikolić, TatjanaUNSPECIFIED
Miškić, BlaženkaUNSPECIFIED
Car, DoloresUNSPECIFIED
Tajsić, GordanaUNSPECIFIED
Dušek, TinaUNSPECIFIED
Jajić, ZrinkaUNSPECIFIED
Grubišić, FraneUNSPECIFIED
Poljičanin, TamaraUNSPECIFIED
Bakula, MiroUNSPECIFIED
Džubur, FedjaUNSPECIFIED
Strižak-Ujević, MatildaUNSPECIFIED
Kadojić, MiraUNSPECIFIED
Radman, MajaUNSPECIFIED
Vugrinec, MajaUNSPECIFIED
Kušter, ŽeljkaUNSPECIFIED
Pekez, MarijetaUNSPECIFIED
Radović, EndiUNSPECIFIED
Labar, LjubicaUNSPECIFIED
Crnčević-Orlić, ŽeljkaUNSPECIFIED
Koršić, MirkoUNSPECIFIED
Date: 2010
Date Deposited: 11 Jan 2012 12:45
Last Modified: 11 Jan 2012 12:45
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1426

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