Systemic thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke: first Croatian experiences

Matijević, Vesna and Alvir, Domagoj and Malojčić, Branko and Unušić, Lea and Šupe, Svjetlana and Boban, Marina and Bujan-Kovač, Andrea and Habek, Mario and Poljaković, Zdravka (2010) Systemic thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke: first Croatian experiences. Neurological Sciences, 31 (6). pp. 693-697. ISSN 1590-1874

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In September 2003, recombinant tissue plasminogen activator (rt-PA) for acute treatment of ischemic stroke was finally approved by the Croatian Ministry of Health. For the next 5 years, only three stroke units in the country implemented this therapy in their routine practice until summer 2008, when neurological wards in most Croatian hospitals started to treat acute stroke patients with systemic thrombolysis. We present a 2-year experience of thrombolytic therapy (2006-2008) in the stroke unit of the University Hospital in Zagreb, Croatian largest hospital, serving nearly one-fifth of the citizens of Croatia. Obtained data (vitals at admission and before administration of rt-PA; NIHSS and MRS scores at admission, 2 h and 7th day after rt-PA treatment, "time to door" and "door to needle" intervals, duration of hospital treatment as well as outcomes and complications of our 66 thrombolysed patients) are presented and discussed. We also present our results regarding benefits of this therapy as well as possible reasons for complications noticed.

Item Type: Article
MeSH: Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Brain Ischemia/drug therapy ; Brain Ischemia/genetics ; Brain Ischemia/mortality ; Croatia/epidemiology ; Female ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/adverse effects ; Humans ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Recombinant Proteins/genetics ; Retrospective Studies ; Stroke/drug therapy ; Stroke/genetics ; Stroke/mortality ; Thrombolytic Therapy/methods ; Thrombolytic Therapy/mortality ; Tissue Plasminogen Activator/administration & dosage ; Tissue Plasminogen Activator/adverse effects ; Tissue Plasminogen Activator/genetics ; Young Adult
Departments: Katedra za neurologiju
Depositing User: Marijan Šember
Status: Published
Matijević, VesnaUNSPECIFIED
Malojčić, BrankoUNSPECIFIED
Šupe, SvjetlanaUNSPECIFIED
Bujan-Kovač, AndreaUNSPECIFIED
Poljaković, ZdravkaUNSPECIFIED
Date: December 2010
Date Deposited: 11 Jan 2012 11:17
Last Modified: 11 Jan 2012 11:17
Subjects: /
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