Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Varicella zoster infection in renal transplant recipients: prevalence, complications and outcome

Mustapić, Željka and Bašić-Jukić, Nikolina and Kes, Petar and Lovčić, Vesna and Bubić-Filipi, Ljubica and Mokos, Ivica and Kaštelan, Željko and Zekan, Šime (2011) Varicella zoster infection in renal transplant recipients: prevalence, complications and outcome. Kidney & Blood Pressure Research, 34 (6). pp. 382-386. ISSN 1420-4096

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    English abstract

    Varicella zoster virus (VZV) is an important pathogen after renal transplantation. In the present study, we examined the prevalence, clinical presentation and outcome of VZV infections in renal transplant recipients. Charts and medical records of adult renal allotransplant recipients were investigated to find patients with VZV infection. From December 1972 until July 2010, 1,139 patients received kidney allograft at our institution. VZV infection was diagnosed in 40 patients (3.51%). 28 patients (70%) had intensified immunosuppression prior to VZV infection occurrence. Median time of onset was 2.13 years after transplantation (range 9 days to 19.2 years). 35 patients developed VZV during the first post-transplant year (median 0.61 years). Four patients developed VZV infection more than 12 years after transplantation. 33 patients (82.5%) had dermatomal distribution, 5 (12.5%) disseminated herpes zoster (HZ), and 2 patients (5%) who were VZV IgG-negative before transplantation, developed chickenpox. Immunosuppression was reduced and patients received acyclovir. Cutaneous scarring was recorded in 7 cases (17.5%). Two patients developed post-herpetic neuralgia, which was accompanied by scarring and skin depigmentation in 1 of them. Five patients (12.5%) experienced relapse of HZ. Timely initiation of therapy may prevent development of complications and the visceral form of disease. Based on our experience with development of chickenpox, we suggest active immunization for all seronegative patients before organ transplantation.

    Item Type: Article
    Divisions: Katedra za internu medicinu
    Katedra za urologiju
    Depositing User: Marijan Šember
    Status: Published
    Mustapić, Željka
    Bašić-Jukić, Nikolina
    Kes, Petar
    Lovčić, Vesna
    Bubić-Filipi, Ljubica
    Mokos, Ivica
    Kaštelan, Željko
    Zekan, Šime
    Date: 2011
    Date Deposited: 10 Jan 2012 18:00
    Last Modified: 10 Jan 2012 18:00
    Subjects: /
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