Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Lidocaine suppository for transrectal ultrasound-guided biopsy of the prostate: a prospective, double-blind, randomized study

Goluža, Eleonora and Hudolin, Tvrtko and Kaštelan, Željko and Perić, Mladen and Murselović, Tamara and Šošić, Hrvoje (2011) Lidocaine suppository for transrectal ultrasound-guided biopsy of the prostate: a prospective, double-blind, randomized study. Urologia Internationalis, 86 (3). pp. 315-319. ISSN 0042-1138

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    English abstract

    AIMS: To investigate analgesia using lidocaine suppositories for prostate biopsy. ----- METHODS: From 2007 to 2009, 160 patients underwent transrectal ultrasound-guided prostate biopsy at the Department of Urology, KBC Zagreb. 80 patients received a 60-mg lidocaine suppository intrarectally at different time points from 15 to 120 min before biopsy and 80 patients received a glycerin suppository as placebo. The pain level was evaluated using a visual analogue scale (VAS). ----- RESULTS: There were no statistically significant differences between the groups, i.e. they were similar regarding patients' age, prostate-specific antigen levels, prostate volume and the incidence of diagnosis of malignancy on biopsy. The mean pain score in the lidocaine group (3 ± 1) was significantly lower than the mean pain score in the glycerin group (4.1 ± 1.3) (p < 0.001). A noticeable trend towards lower pain scores in the lidocaine group was observed with more time elapsing from placing the suppository till the biopsy and the optimal time for performing biopsy starting approximately 1 h after placing the suppository. ----- CONCLUSIONS: Lidocaine suppositories are an easy-to-use, self-applicable (by the patient) and cheap method of local analgesia, with acceptable results. Possible complications related to this procedure are insignificant.

    Item Type: Article
    MeSH: Aged ; Anesthetics, Local/administration & dosage ; Biopsy ; Double-Blind Method ; Glycerol/chemistry ; Humans ; Lidocaine/administration & dosage ; Male ; Middle Aged ; Placebos ; Prospective Studies ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/ultrasonography ; Rectum/ultrasonography ; Suppositories ; Treatment Outcome ; Ultrasonography/methods
    Divisions: Katedra za urologiju
    Depositing User: Marijan Šember
    Status: Published
    Goluža, Eleonora
    Hudolin, Tvrtko
    Kaštelan, Željko
    Perić, Mladen
    Murselović, Tamara
    Šošić, Hrvoje
    Date: 2011
    Date Deposited: 10 Jan 2012 13:46
    Last Modified: 10 Jan 2012 13:48
    Subjects: /
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