The influence of the different morphological changes on gastric mucosa on somatostatin cell number in antrum mucosa and serum somatostatin

Mihaljević, Silvio and Katičić, Miroslava and Krznarić, Željko and Dmitrović, Branko and Karner, Ivan and Štefanić, Mario and Pinotić, Ljerka and Samardžija, Marina and Benšić, Mirta (2011) The influence of the different morphological changes on gastric mucosa on somatostatin cell number in antrum mucosa and serum somatostatin. Collegium Antropologicum, 35 (1). pp. 5-8. ISSN 0350-6134

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Abstract

The aim of our paper was to investigate the influence of the different morphological changes on gastric mucosa on somatostatin D-cell number in antral mucosa and serum Somatostatin. We analyzed according to Sydney classification to what extent the severity of gastritis affect the observed hormonal values. somatostatin D-cell number in antral mucosa and serum Somatostatin values were compared between three groups of patients; mild, moderate and severe chronic gastritis. The average number of somatostatin cell in biopsy sample of antrum mucosa was 30.41 +/- 35.38 (N = 17) in the case of middle form, 18.69 +/- 26.65 (N = 56) in moderate and in severe case of chronic gastritis 5.23 +/- 5.93 (N = 7) cells in mm2 of mucosa. The level of somatostatin in the serum of middle form gastritis were 26.43 +/- 28.76, moderate 19.95 +/- 35.93 and severe 17.88 +/- 17.66 pg/mL. In order to determine the number of somatostatin cells in antrum mucosa and serum somatostatin with present morphological changes of mucosa, it might helpful to exclude the patients with non-ulcer dyspepsia, but with the higher risk of premalignant and malignant changes.

Abstract in Croatian

UTJECAJ RAZLIČITIH MORFOLOŠKIH PROMJENA ŽELUČANE SLUZNICE NA BROJ SOMATOSTATINSKIH STANICA U SLUZNICI ANTRUMA ŽELUCA I VRIJEDNOSTI SOMATOSTATINA U SERUMU ----- U ovom radu istražili smo utjecaj različitih morfoloških promjena želučane sluznice na broj somatostatinskih D stanica sluznice antruma želuca i serumski somatostatin. Prema Sydnejskoj klasifikaciji gastritisa analizirali smo koliko jačina upalnih promjena sluznice želuca utječe na promatrane vrijednosti hormona. Broj somatostatinskih D stanica u sluznici antruma želuca i vrijednosti serumskog somatostatina uspoređivali smo kod tri grupe pacijenata: s blagim, umjerenim i teškim kroničnim gastritisom. Prosječni broj somatostatinskih stanica u bioptičkom uzorku sluznice antruma bio je 30,41±35,38 (N=17) u blagom gastritisu, 18,69±26,65 (N=56) u umjereno teškom i 5,23±5,93 (N=7) stanica umm2 sluznice. Vrijednosti serumskog somatostatina u blagom gastritisu bile su 26,43±28,76, umjerenom 19,95±35,93 i teškom obliku 17,88±17,66 pg/mL. Određivanje broja somatostatinskih stanica sluznice antruma želuca i serumskog somatostatina kod određenih morfoloških promjena želučane sluznice može nam pomoći da izdvojimo pacijente s neulkusnom dispepsiom te one koji imaju veliki rizik od razvoja premalignih i malignih promjena.

Item Type: Article
MeSH: Cohort Studies ; Gastric Mucosa/cytology ; Gastric Mucosa/pathology ; Gastritis/blood ; Gastritis/pathology ; Humans ; Somatostatin/blood ; Somatostatin-Secreting Cells/cytology ; Somatostatin-Secreting Cells/pathology
Departments: Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Mihaljević, SilvioUNSPECIFIED
Katičić, MiroslavaUNSPECIFIED
Krznarić, ŽeljkoUNSPECIFIED
Dmitrović, BrankoUNSPECIFIED
Karner, IvanUNSPECIFIED
Štefanić, MarioUNSPECIFIED
Pinotić, LjerkaUNSPECIFIED
Samardžija, MarinaUNSPECIFIED
Benšić, MirtaUNSPECIFIED
Date: March 2011
Date Deposited: 25 Nov 2011 12:32
Last Modified: 25 Nov 2011 12:32
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1392

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