Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase

Višnjić, Dora and Banfić, Hrvoje (2007) Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase. Pflügers Archiv : European Journal of Physiology, 455 (1). pp. 19-30. ISSN 0031-6768 (Print) 1432-2013 (Electronic)

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    English abstract

    Over the last 20 years, numerous studies have demonstrated the existence of nuclear phosphoinositide signaling distinct from the one at the plasma membrane. The activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphoinositide 3-kinase (PI3K), the generation of diacylglycerol, and the accumulation of the 3-phosphorylated phosphoinositides have been documented in the nuclei of different cell types. In this review, we summarize some recent studies of the subnuclear localization, mechanisms of activation, and the possible physiological roles of the nuclear PI-PLC and PI-3 kinases in the regulation of cell cycle, survival, and differentiation.

    Item Type: Article
    MeSH: 1-Phosphatidylinositol 3-Kinase - physiology ; Cell Nucleus - enzymology - physiology ; Phosphoinositide Phospholipase C - physiology ; Phospholipids - physiology ; Signal Transduction - physiology ; Animals ; Cell Cycle - physiology ; Cell Differentiation - physiology ; Humans ; Mitosis - physiology
    Divisions: Katedra za fiziologiju i imunologiju
    Hrvatski institut za istraživanje mozga
    Depositing User: Lea Škorić
    Status: Published
    Creators:
    CreatorsEmail
    Višnjić, Dora
    Banfić, Hrvoje
    Date: October 2007
    Date Deposited: 12 Oct 2007
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/139

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