Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase

Višnjić, Dora and Banfić, Hrvoje (2007) Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase. Pflügers Archiv : European Journal of Physiology, 455 (1). pp. 19-30. ISSN 0031-6768 (Print) 1432-2013 (Electronic)

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Abstract

Over the last 20 years, numerous studies have demonstrated the existence of nuclear phosphoinositide signaling distinct from the one at the plasma membrane. The activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphoinositide 3-kinase (PI3K), the generation of diacylglycerol, and the accumulation of the 3-phosphorylated phosphoinositides have been documented in the nuclei of different cell types. In this review, we summarize some recent studies of the subnuclear localization, mechanisms of activation, and the possible physiological roles of the nuclear PI-PLC and PI-3 kinases in the regulation of cell cycle, survival, and differentiation.

Item Type: Article
MeSH: 1-Phosphatidylinositol 3-Kinase - physiology ; Cell Nucleus - enzymology - physiology ; Phosphoinositide Phospholipase C - physiology ; Phospholipids - physiology ; Signal Transduction - physiology ; Animals ; Cell Cycle - physiology ; Cell Differentiation - physiology ; Humans ; Mitosis - physiology
Departments: Katedra za fiziologiju i imunologiju
Hrvatski institut za istraživanje mozga
Depositing User: Lea Škorić
Status: Published
Creators:
CreatorsEmail
Višnjić, DoraUNSPECIFIED
Banfić, HrvojeUNSPECIFIED
Date: October 2007
Date Deposited: 12 Oct 2007
Last Modified: 23 Sep 2011 16:09
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/139

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