Višnjić, Dora and Banfić, Hrvoje (2007) Nuclear phospholipid signaling: phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase. Pflügers Archiv : European Journal of Physiology, 455 (1). pp. 19-30. ISSN 0031-6768
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Abstract
Over the last 20 years, numerous studies have demonstrated the existence of nuclear phosphoinositide signaling distinct from the one at the plasma membrane. The activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and phosphoinositide 3-kinase (PI3K), the generation of diacylglycerol, and the accumulation of the 3-phosphorylated phosphoinositides have been documented in the nuclei of different cell types. In this review, we summarize some recent studies of the subnuclear localization, mechanisms of activation, and the possible physiological roles of the nuclear PI-PLC and PI-3 kinases in the regulation of cell cycle, survival, and differentiation.
| Item Type: | Article | ||||||
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| MeSH: | 1-Phosphatidylinositol 3-Kinase - physiology ; Cell Nucleus - enzymology - physiology ; Phosphoinositide Phospholipase C - physiology ; Phospholipids - physiology ; Signal Transduction - physiology ; Animals ; Cell Cycle - physiology ; Cell Differentiation - physiology ; Humans ; Mitosis - physiology | ||||||
| Departments: | Hrvatski institut za istraživanje mozga Katedra za fiziologiju i imunologiju |
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| Depositing User: | Lea Škorić | ||||||
| Status: | Published | ||||||
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| Date: | October 2007 | ||||||
| Date Deposited: | 12 Oct 2007 | ||||||
| Last Modified: | 10 Dec 2019 08:58 | ||||||
| Subjects: | / | ||||||
| Related URLs: | |||||||
| URI: | http://medlib.mef.hr/id/eprint/139 |
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