Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Predicted coronary heart disease risk in croatian HIV infected patients treated with combination antiretroviral therapy

Turčinov, Drago and Begovac, Josip (2011) Predicted coronary heart disease risk in croatian HIV infected patients treated with combination antiretroviral therapy. Collegium Antropologicum, 35 (1). pp. 115-21. ISSN 0350-6134

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    Croatian abstract

    PREDVIĐANJE RIZIKA KORONARNE BOLESTI SRCA U SUDIONIKA ZARAŽENIH HIV-OM IZ HRVATSKE LIJEČENIH CART-OM ----- Procijenili smo rizik koronarne bolesti (KB) u 130 sudionika zaraženih HIV-om, liječenih kombinacijom antiretrovirusnih lijekova (CART) koji nisu ranije imali veća kardiovaskularna oštećenja od svibnja 2004 do lipnja 2005. Također smo istražili povezanosti parametara HIV bolesti (broj CD4+ T stanica, stupanj HIV-viremije, AIDS dijagnoza, antiretrovirusni lijekovi, lipodistrofija) demografske, antropometrijske, kliničke odlike, pušački status, dislipidemiju, pridržavanje mediteranskoj prehrani i metabolički sindrom (MS) u odnosu na računanje Framingham-ovog rizika. Medijan desetgodišnjeg rizika KB je 6,4% (IQR 3,3–13,0) za muške i 1,8% (IQR 1,0–6,7) za ženske. Rizik od KB > ili = 10% je 31,1% (32 od 103) u muških i 14,8% (4 od 27) u ženskih. MS je bio prisutan u 27 (20,8%) pojedinaca. Sudionici sa MS imali su 2,63 puta veću šansu imati rizik KB > ili = 10% (95% CI 1,09–6,39; p=0,032). U multivarijatnoj analizi našli smo da će ispitanici imati rizik KB > ili = 10%: ako su ikad imali broj CD4+ T-stanica manje od 50 po mikrolitru i AIDS definirajuću bolest u anamnezi (OR 6,26; 95% CI 1,61–24,36; p=0.008); konzumirali alkohol > ili = 10 g/dnevno (OR, 3,87; 95% CI 1,56–14,22; p=0,041); i bili u dobi > ili = 43 godine (OR, 1,30; 95% CI 1,17–1,45; p<0,001). Potrebne su intervencije koje smanjuju promjenjive kardiovaskularne rizike u hrvatskih bolesnika koji se liječe CART-om.

    English abstract

    We assessed the coronary heart disease (CHD) risk in 130 HIV-infected patients with no major past cardiovascular event treated with combination antiretroviral therapy (CART) between May 2004 and June 2005. We also investigated the association of HIV disease parameters (CD4 + T-cell counts, HIV viral load, AIDS diagnosis, antiretroviral medications and lipodystrophy), demographics, anthropometrics, clinical features, smoking status, dyslipidemia, adherence to the Mediterranean diet, and the metabolic syndrome (MS) to the Framingham risk score. The median 10-year CHD risk was 6.4% (IQR 3.3-13.0) for males and 1.8% (IQR 1.0-6.7) for females. The CHD risk was > or = 10% in 31.1% (32 of 103) males and in 14.8% (4 of 27) females. MS was present in 27 (20.8%) individuals. Participants who met the definition of the MS had a 2.63 times greater chance of having a CHD risk 210% (95% CI, 1.09-6.39; p = 0.032). On multivariable analysis, we found that a CHD risk > or = 10% was associated with: a lowest ever CD4+ T-cell counts of less than 50 per microliter and a past history of AIDS (OR, 6.26; 95% CI, 1.61-24.36; p = 0.008); alcohol consumption 210 g/day (OR, 3.87; 95% CI, 1.56-14.22; p = 0.041); and age 243 years (OR, 1.30; 95% CI, 1.17-1.45; p < 0.001). Interventions to reduce the modifiable cardiovascular risk are needed in Croatian patients treated with CART

    Item Type: Article
    MeSH: Adult ; Anti-HIV Agents/therapeutic use ; Coronary Disease/virology ; Croatia ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Risk Factors
    Divisions: Katedra za infektologiju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Turčinov, Drago
    Begovac, Josip
    Date: March 2011
    Date Deposited: 03 Nov 2011 13:45
    Last Modified: 03 Nov 2011 13:45
    Subjects: /
    Related URLs:
    URI: http://medlib.mef.hr/id/eprint/1374

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