Downbeat nystagmus, ataxia and spastic tetraparesis due to coeliac disease

Habek, Mario and Hojsak, Iva and Barun, Barbara and Brinar, Vesna V. (2011) Downbeat nystagmus, ataxia and spastic tetraparesis due to coeliac disease. Neurological Sciences, 32 (5). pp. 911-4. ISSN 1590-1874

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Abstract

A 25-year-old female presented to a university neurology clinic with a 1-month history of progressive ataxia, downbeat nystagmus and spastic tetraparesis. Personal history revealed polyarthralgias and weight loss. Family history was negative. Following thorough history, laboratory, neurophysiological and MRI investigations, a diagnosis of cerebellar ataxia due to coeliac disease was done. The patient was treated with strict gluten-free diet and intravenous administration of immunoglobulins. Although there are many controversies about neurological manifestations of coeliac disease, this case pointed to strong association between these two disorders. The findings of elevated protein content in the cerebrospinal fluid with positive oligoclonal bands suggested an immune-mediated process, further supported by positive anti-endomysium antibodies and anti-transglutaminase antibodies in the cerebrospinal fluid.

Item Type: Article
Departments: Katedra za neurologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Habek, MarioUNSPECIFIED
Hojsak, IvaUNSPECIFIED
Barun, BarbaraUNSPECIFIED
Brinar, Vesna V.UNSPECIFIED
Date: October 2011
Date Deposited: 25 Oct 2011 12:29
Last Modified: 25 Oct 2011 12:42
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/1361

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