Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa [The effect of pentadecapeptide BPC 157 on reflux esophagitis during acute pancreatitis]

Dobrić, Ivan (2011) Učinak pentadekapeptida BPC 157 na refluksni ezofagitis tijekom akutnog pankreatitisa [The effect of pentadecapeptide BPC 157 on reflux esophagitis during acute pancreatitis]. PhD thesis, Sveučilište u Zagrebu.

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    Croatian abstract

    Cilj istraživanja bio je pojava i progresija duodenogastroezofagealnog refluksa te njegova pogoršanja uslijed induciranog pankreatitisa te istraživanje potencijelnih terapijskih mogućnosti pentadekapeptida BPC 157. Do sada su u više navrata opisane sistemske komplikacije akutnog pankreatitisa. Osim opisanih, akutni pankreatitis dovodi i do komplikacija vezanih uz integritet i motilitet probavnog trakta, od kojih su do sada najčešće opisane one vezane za želudac i duodenum, dok su komplikacije na jednjaku vrlo slabo poznate. Istraživanje je provedeno na ženkama Wistar Albino štakora. Duodenogastroezofagealni refluks induciran je implantacijom cjevčice u pilorički sfinkter, dok je akutni pankreatitis induciran podvezivanjem glavnoga žučnog voda ispred otvaranja u duodenum. Istraženi su i opisani učinci pentadekapeptida BPC 157 na makroskopske i histološke promjene sluznice jednjaka te na tlak donjega ezofagealnog sfinktera, kao i na makroskopske, histološke i biokemijske promjene uslijed akutnog pankreatitisa. Rezultati su evaluirani nakon 24 sata. Bez obzira na akutni pankreatitis, pentadekapeptid BPC 157 održava tonus DES, sprečava nastanak makroskopski vidljivih promjena jednjaka i oštećenja integriteta rožnatog sloja sluznice jednjaka. Bez obzira na to što je kod svih životinja došlo do pojave akutnog pankreatitisa, u tretiranih je životinja verificirana niža serumska koncentracija lipaza, a opažen je i povoljan učinak u sprečavanju nastanka edema i nekroze pankreasa.

    English abstract

    The development of of duodenogastroesophageal reflux, it's worsening related to acute pancreatitis, and potential therapeutic effect of pentadecapeptie BPC 157 were the main goals of this research. Systemic complications of acute pancreatitis were described in numerous articles. The acute pancreatitis also badly influences digestive integrity and motility. This effects are mostly known to be developed in stomach and duodenum, while esophagus complications are poorly described and understood. The female Wistar albino rats were used in this research. Duodenogastroesophageal reflux was induced by implanting the plastic tube through pylorus, amd acute pancreatitis by ligating main bile duct just proximally to it's entering into duodenum. The results were evaluated after 24 hours. The effect of pentadecapeptide BPC 157 is described through the results describing macroscopical and hystological changes, the lowers esophageal sphyncter pressure, as well as macroscopic, hystologic and biochemical changes caused by acute pancreatitis. Despite the acute pancreatitis developed, pentadecapeptide BPC 157 keeps the lower esophageal sphyncter strenght, prevents macroscopically identified esophageal changes, and protects corneal layer integrity. Although all the animals developed acute pancreatitis, the lipase serum level concentration was lower in treated animals, as well as edema and necrosis.

    Item Type: Thesis (PhD)
    Mentor: Majerović, Mate
    Divisions: Izvan medicinskog fakulteta
    Depositing User: Marijan Šember
    University: Sveučilište u Zagrebu
    Institution: Medicinski fakultet
    Number of Pages: 122
    Status: Unpublished
    Creators:
    CreatorsEmail
    Dobrić, Ivan
    Date: 22 July 2011
    Date Deposited: 12 Oct 2011 12:20
    Last Modified: 12 Oct 2011 12:20
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/1349

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