Barišić, Nina and Chaouch, Amina and Müller, Juliane S. and Lochmüller, Hanns
Genetic heterogeneity and pathophysiological mechanisms in congenital myasthenic syndromes.
European Journal of Paediatric Neurology, 15 (3).
Congenital myasthenic syndromes (CMS) are a rare heterogeneous group of inherited neuromuscular disorders associated with distinctive clinical, electrophysiological, ultrastructural and genetic abnormalities. These genetic defects either impair neuromuscular transmission directly or result in secondary impairments, which eventually compromise the safety margin of neuromuscular transmission. In this report we will explore the significant progress made in understanding the molecular pathogenesis of CMS, which is important for both patients and clinicians in terms of reaching a definite diagnosis and selecting the most appropriate treatment.
||Katedra za pedijatriju
|Müller, Juliane S.||UNSPECIFIED|
||01 Sep 2011
||23 Sep 2011 16:12
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