Genetic heterogeneity and pathophysiological mechanisms in congenital myasthenic syndromes

Barišić, Nina and Chaouch, Amina and Müller, Juliane S. and Lochmüller, Hanns (2011) Genetic heterogeneity and pathophysiological mechanisms in congenital myasthenic syndromes. European Journal of Paediatric Neurology, 15 (3). pp. 189-96. ISSN 1090-3798

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Abstract

Congenital myasthenic syndromes (CMS) are a rare heterogeneous group of inherited neuromuscular disorders associated with distinctive clinical, electrophysiological, ultrastructural and genetic abnormalities. These genetic defects either impair neuromuscular transmission directly or result in secondary impairments, which eventually compromise the safety margin of neuromuscular transmission. In this report we will explore the significant progress made in understanding the molecular pathogenesis of CMS, which is important for both patients and clinicians in terms of reaching a definite diagnosis and selecting the most appropriate treatment.

Item Type: Article
Departments: Katedra za pedijatriju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Barišić, NinaUNSPECIFIED
Chaouch, AminaUNSPECIFIED
Müller, Juliane S.UNSPECIFIED
Lochmüller, HannsUNSPECIFIED
Date: May 2011
Date Deposited: 01 Sep 2011
Last Modified: 23 Sep 2011 16:12
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/1003

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